F
Flora C.Y. Lee
Researcher at Francis Crick Institute
Publications - 14
Citations - 705
Flora C.Y. Lee is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: RNA-binding protein & RNA. The author has an hindex of 5, co-authored 9 publications receiving 237 citations. Previous affiliations of Flora C.Y. Lee include UCL Institute of Neurology.
Papers
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Journal ArticleDOI
Advances in CLIP Technologies for Studies of Protein-RNA Interactions
TL;DR: The rationale for each step in the UV crosslinking and immunoprecipitation protocol is described and the impact of variations are discussed to help users determine the most suitable option.
Journal ArticleDOI
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Anna L. Brown,Oscar G. Wilkins,Matthew J. Keuss,Sarah E. Hill,Matteo Zanovello,Weaverly Colleen Lee,Alexander Bampton,Flora C.Y. Lee,Laura Masino,Yue Qi,S. Bryce-Smith,Ariana Gatt,Martina Hallegger,Delphine Fagegaltier,Hemali Phatnani,Jia Newcombe,Emil K. Gustavsson,Sahba Seddighi,Joel F. Reyes,Steven L. Coon,Daniel M. Ramos,Giampietro Schiavo,Elizabeth M. C. Fisher,Towfique Raj,Maria Secrier,Tammaryn Lashley,Jernej Ule,Emanuele Buratti,Jack Humphrey,Michael E. Ward,Pietro Fratta +30 more
TL;DR: In this article , the authors show that TDP-43 depletion induces robust inclusion of a cryptic exon in UNC13A , resulting in nonsense-mediated decay and loss of UNC13a protein.
Journal ArticleDOI
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
A Brown,Oscar G. Wilkins,Matthew J. Keuss,Sarah E. Hill,Matteo Zanovello,Weaverly Colleen Lee,Alexander Bampton,Flora C.Y. Lee,Laura Masino,Yue Qi,S. Bryce-Smith,Ariana Gatt,Martina Hallegger,Delphine Fagegaltier,Hemali Phatnani,Justin Y. Kwan,Dhruv Sareen,James R. Broach,Zachary Simmons,Ximena Arcila-Londono,Edward B. Lee,Vivianna M. Van Deerlin,Neil A. Shneider,Ernest Fraenkel,Lyle W. Ostrow,Frank Baas,Noah Zaitlen,James D. Berry,Andrea Malaspina,Gregory A. Cox,Leslie M. Thompson,Steven Finkbeiner,Efthimios Dardiotis,Timothy M. Miller,Siddharthan Chandran,Suvankar Pal,Eran Hornstein,Daniel MacGowan,Terry Heiman-Patterson,Molly Hammell,Nikolaos A. Patsopoulos,Oleg Butovsky,Josh Dubnau,Avindra Nath,Robert Bowser,Matthew M Harms,Eleonora Aronica,Mary Poss,Jennifer E. Phillips-Cremins,John F. Crary,Nazem Atassi,D. J. Lange,Darius J. Adams,Leonidas Stefanis,Marc Gotkine,Robert W. Baloh,Suma Babu,Towfique Raj,Sabrina Paganoni,Ophir Shalem,Colin Smith,Bin Zhang,B. Harris,Iris J. Broce,Vivian E. Drory,John Ravits,Corey T. McMillan,Vilas Menon,Lani F. Wu,Steven J. Altschuler,Yossef Lerner,Rita Sattler,Kendall Van Keuren-Jensen,Orit Rozenblatt-Rosen,Kerstin Lindblad-Toh,Katharine Nicholson,Peter K. Gregersen,Jeong Ho Lee,Sulev Kokos,Stephen Muljo,Jia Newcombe,Emil K. Gustavsson,Sahba Seddighi,Joel F. Reyes,Steven L. Coon,Daniel M. Ramos,Giampietro Schiavo,Elizabeth M. C. Fisher,Maria Secrier,Tammaryn Lashley,Jernej Ule,Emanuele Buratti,Jack Humphrey,Michael E. Ward,Pietro Fratta +94 more
TL;DR: In this article , the authors show that TDP-43 depletion induces robust inclusion of a cryptic exon in UNC13A , resulting in nonsense-mediated decay and loss of UNC13a protein.
Journal ArticleDOI
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
Miha Modic,Miha Modic,Markus Grosch,Gregor Rot,Silvia Schirge,Tjasa Lepko,Tomohiro Yamazaki,Flora C.Y. Lee,Flora C.Y. Lee,Ejona Rusha,Dmitry Shaposhnikov,Michael Z. Palo,Michael Z. Palo,Juliane Merl-Pham,Davide Cacchiarelli,Boris Rogelj,Stefanie M. Hauck,Christian von Mering,Alexander Meissner,Alexander Meissner,Heiko Lickert,Tetsuro Hirose,Jernej Ule,Jernej Ule,Micha Drukker +24 more
TL;DR: It is demonstrated that cross-regulation between TDP-43 and Neat1 is essential for their efficient regulation of a broad network of genes and, therefore, of pluripotency and differentiation.
Journal ArticleDOI
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
Martina Hallegger,Martina Hallegger,Anob M. Chakrabarti,Flora C.Y. Lee,Flora C.Y. Lee,Bo Lim Lee,Aram G. Amalietti,Aram G. Amalietti,Hana M. Odeh,Katie E. Copley,Jack D. Rubien,Bede Portz,Klara Kuret,Ina Huppertz,Frédérique Rau,Frédérique Rau,Rickie Patani,Rickie Patani,Nicolas L. Fawzi,James Shorter,Nicholas M. Luscombe,Nicholas M. Luscombe,Jernej Ule,Jernej Ule +23 more
TL;DR: In this paper, a series of TDP-43 C-terminal domain (CTD) variants exhibited a gradient of low to high condensation propensity, as observed in vitro and by nuclear mobility and foci formation.