Temporal hierarchy of intrinsic neural timescales converges with spatial core-periphery organization.
Mehrshad Golesorkhi,Mehrshad Golesorkhi,Javier Gomez-Pilar,Shankar Tumati,Shankar Tumati,Maia Fraser,Georg Northoff,Georg Northoff,Georg Northoff +8 more
- Vol. 4, Iss: 1, pp 277-277
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TLDR
In this article, the autocorrelation window in short (ACW-50) and long ACW-0 windows were used to investigate intrinsic neural timescales during rest and task states.Abstract:
The human cortex exhibits intrinsic neural timescales that shape a temporal hierarchy. Whether this temporal hierarchy follows the spatial hierarchy of its topography, namely the core-periphery organization, remains an open issue. Using magnetoencephalography data, we investigate intrinsic neural timescales during rest and task states; we measure the autocorrelation window in short (ACW-50) and, introducing a novel variant, long (ACW-0) windows. We demonstrate longer ACW-50 and ACW-0 in networks located at the core compared to those at the periphery with rest and task states showing a high ACW correlation. Calculating rest-task differences, i.e., subtracting the shared core-periphery organization, reveals task-specific ACW changes in distinct networks. Finally, employing kernel density estimation, machine learning, and simulation, we demonstrate that ACW-0 exhibits better prediction in classifying a region’s time window as core or periphery. Overall, our findings provide fundamental insight into how the human cortex’s temporal hierarchy converges with its spatial core-periphery hierarchy. Golesorkhi et al. use a combination of magnetoencephalography data, machine learning and simulation to investigate intrinsic neural timescales during resting and task states. They provide insight into how the temporal hierarchy of the human cortex converges with its spatial core-periphery hierarchy.read more
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Journal ArticleDOI
Intrinsic neural timescales: temporal integration and segregation
Annemarie Wolff,Nareg Berberian,Mehrshad Golesorkhi,Javier Gomez-Pilar,Federico Zilio,Georg Northoff +5 more
TL;DR: In this paper , a hierarchy of intrinsic neural timescales (INT) with a shorter duration in unimodal regions and a longer duration in transmodal regions (e.g., default mode network) was found to be central to the temporal integration and segregation of external inputs from the environment.
Journal ArticleDOI
The brain and its time: intrinsic neural timescales are key for input processing
Mehrshad Golesorkhi,Mehrshad Golesorkhi,Javier Gomez-Pilar,Federico Zilio,Nareg Berberian,Annemarie Wolff,Mustapha C. E. Yagoub,Georg Northoff,Georg Northoff,Georg Northoff +9 more
TL;DR: In this paper, the authors show that the brain displays a complex multiscale temporal organization, which is described by the concept of intrinsic neural timescales (INT); however, their function and neural mechanisms remains unclear.
Journal ArticleDOI
Temporo-spatial Theory of Consciousness (TTC) – Bridging the gap of neuronal activity and phenomenal states
Georg Northoff,Federico Zilio +1 more
TL;DR: The Temporo-spatial Theory of Consciousness (TTC) as mentioned in this paper proposes four temporo-space mechanisms: expansion, globalization, alignment, and nestedness, which are associated with distinct dimensions of consciousness including phenomenal content, access, form/structure, and level/state.
Journal ArticleDOI
When makes you unique: Temporality of the human brain fingerprint.
Dimitri Van De Ville,Dimitri Van De Ville,Younes Farouj,Younes Farouj,Maria Giulia Preti,Maria Giulia Preti,Raphaël Liégeois,Raphaël Liégeois,Enrico Amico,Enrico Amico +9 more
TL;DR: The extraction of fingerprints from human brain connectivity data has become a new frontier in neuroscience as discussed by the authors, however, the time scales of human brain identifiability are still largely unexplored.
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Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.
TL;DR: This discovery was a breakthrough in the current rapid development of protein-degrading agents because clarification of the mechanism of action of thalidomide derivatives has demonstrated the clinical value of these compounds.
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