Journal ArticleDOI
The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site
TLDR
The kinetic and pharmacological characteristics of the binding of ligands to frontal cortex and hippocampus demonstrated the presence of 5-HT1 and5-HT2 sites in both tissues, although hippocampus was richer in 5-ht1 (subtype 5- HT1A) sites.About:
This article is published in European Journal of Pharmacology.The article was published on 1984-11-27. It has received 602 citations till now. The article focuses on the topics: Mesulergine & Choroid plexus.read more
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A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
Journal ArticleDOI
Structure and function of the brain serotonin system.
Journal ArticleDOI
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.
Angel Pazos,José Palacios +1 more
TL;DR: The distribution of serotonin-1 (5-HT1) receptors in the rat brain was studied by light microscopic quantitative autoradiography and the existence of 'selective' areas allowed a detailed pharmacological characterization of these sites to be made in a more precise manner than has been attained in membrane-binding studies.
Journal ArticleDOI
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
P.B. Bradley,G. Engel,Wasyl Feniuk,John R. Fozard,Patrick P.A. Humphrey,Derek N. Middlemiss,Ewan J. Mylecharane,B.P. Richardson,Pramod R. Saxena +8 more
TL;DR: This classification of 5-HT receptors into three main groups is based largely, but not exclusively, on data from studies in isolated peripheral tissues where definitive classification is possible, and is believed that this working classification will be relevant to functional responses to 5- HT in the central nervous system.
Journal ArticleDOI
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
A. Schotte,P.F.M. Janssen,W. Gommeren,Walter Luyten,P. Van Gompel,A S Lesage,K. De Loore,J. E. Leysen +7 more
TL;DR: In vitro, all compounds, except the ‘typical’ antipsychotics haloperidol and fluspirilene, showed higher affinity for 5HT2A than for D2 receptors, while in vivo, ORG-5222, risperidone, pipamperone, 9-OH-risperid one, sertindole, olanzapine, zotepine and clozapine maintained a higher potency for occupying 5HT
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.
TL;DR: The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups.
Journal ArticleDOI
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
TL;DR: In this paper, a ternary complex model was used to fit the data with high accuracy under conditions where the ligand used is either a full or a partial agonist and where the system is altered by the addition of guanine nucleotide or after treatment with group-specific reagents.
Journal Article
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
TL;DR: It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
Journal ArticleDOI
Endogenous pain control mechanisms: review and hypothesis.
TL;DR: Evidence is presented that the intrinsic neural network that monitors and modulates the activity of pain‐transmitting neurons is mediated in part by endogenous opiatelike compounds (endorphins).
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Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors.
Angel Pazos,José Palacios +1 more