The Cerebellum, Sensitive Periods, and Autism
TLDR
Evidence that the cerebellum may guide the maturation of remote nonmotor neural circuitry and influence cognitive development and it is proposed that sensitive-period disruption of such internal brain communication can account for autism's key features is reviewed.About:
This article is published in Neuron.The article was published on 2014-08-06 and is currently open access. It has received 603 citations till now. The article focuses on the topics: Autism & Cerebellum.read more
Citations
More filters
Journal ArticleDOI
Advancing the understanding of autism disease mechanisms through genetics
TL;DR: Current understanding of the genetic architecture of ASD is reviewed and genetic evidence, neuropathology and studies in model systems with how they inform mechanistic models of ASD pathophysiology are integrated.
Journal ArticleDOI
The Cerebellum: Adaptive Prediction for Movement and Cognition.
TL;DR: This work examines how two key concepts that have been suggested as general computational principles of cerebellar function- prediction and error-based learning- might be relevant in the operation of cognitive cerebro-cerebellar loops.
Journal ArticleDOI
Consensus Paper: Cerebellum and Emotion
Michael Adamaszek,Federico D'Agata,Roberta Ferrucci,Christophe Habas,Stefanie Keulen,Stefanie Keulen,Kenneth C. Kirkby,Maria Leggio,Peter Mariën,Marco Molinari,Eric A. Moulton,Laura Orsi,F Van Overwalle,Christos Papadelis,Benedetto Sacchetti,Dennis J.L.G. Schutter,Charis Styliadis,Jo Verhoeven,Jo Verhoeven +18 more
TL;DR: Results of this consensus paper illustrate how theory and empirical research have converged to produce a composite picture of brain topography, physiology, and function that establishes the role of the cerebellum in many aspects of emotional processing.
Journal ArticleDOI
Cerebellar modulation of the reward circuitry and social behavior
TL;DR: This work hypothesized that the cerebellum may contribute to motivated behavior by a direct projection to the ventral tegmental area (VTA), a structure that is critical for the perception of reward and control of social behaviors, and proposed a Cb-VTA pathway that may explain, at least in part, the association between the Cerebellum and addictive behaviors.
Journal ArticleDOI
Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder
Arjun Krishnan,Ran Zhang,Victoria Yao,Chandra L. Theesfeld,Aaron K. Wong,Alicja Tadych,Natalia Volfovsky,Alan Packer,Alex E. Lash,Olga G. Troyanskaya +9 more
TL;DR: A complementary machine-learning approach based on a human brain-specific gene network is developed to present a genome-wide prediction of autism risk genes, including hundreds of candidates for which there is minimal or no prior genetic evidence.
References
More filters
Journal ArticleDOI
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TL;DR: In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.
Journal ArticleDOI
Contributions of anterior cingulate cortex to behaviour.
TL;DR: The cingulate epilepsy syndrome provides important support of experimental animal and human functional imaging studies for the role of anterior cingulates cortex in movement, affect and social behaviours.
Journal ArticleDOI
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.