Journal ArticleDOI
The colloidal properties of surfactant-free biodegradable nanospheres from poly(β-malic acid-co-benzyl malate)s and poly(lactic acid-co-glycolide)
Snjezana Stolnik,Martin C. Garnett,M. C. Davies,Lisbeth Illum,M Bousta,Michel Vert,S.S. Davis +6 more
TLDR
In this article, the colloidal properties of surfactant-free nanospheres prepared from biodegradable polyesters have been investigated and the results reveal a significant difference in colloidal behaviour of the nanosphere systems, depending on the composition of the copolymer used in their preparation.About:
This article is published in Colloids and Surfaces A: Physicochemical and Engineering Aspects.The article was published on 1995-04-28. It has received 93 citations till now. The article focuses on the topics: PLGA & Zeta potential.read more
Citations
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Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
TL;DR: The mechanism of rapid escape is by selective reversal of the surface charge of NPs (from anionic to cationic) in the acidic endolysosomal compartment, which causes the NPs to interact with the endo‐lysosomal membrane and escape into the cytosol.
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PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.
TL;DR: It was found that an aqueous phase pH of 9.3, replacement of procaine hydrochloride with procaine dihydrate and the incorporation of PMMA-MA, lauric and caprylic acid into the formulation could enhance drug incorporation efficiency without the size, morphology and nanoparticle recovery being adversely influenced.
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Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake.
TL;DR: The residual PVA associated with nanoparticles is an important formulation parameter that can be used to modulate the pharmaceutical properties of PLGA nanoparticles.
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Long circulating microparticulate drug carriers
TL;DR: This review focuses on the physicochemical and biological properties of polymeric particulate carriers in the nanometre size range surface modified by poly(ethylene oxide) (PEO).
Journal ArticleDOI
Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers.
TL;DR: The techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed and the proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective.
References
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Journal ArticleDOI
Colloid stabilization with grafted polyelectrolytes
TL;DR: In this paper, a simple theory for the scaling properties of the corona thickness, counterion distribution, and disjoining pressure between opposing layers is presented which makes contact with previous numerical studies.
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Biodegradable materials of poly(l-lactic acid): 1. Melt-spun and solution-spun fibres
TL;DR: In this article, the tensile strength of poly(l-lactic) PLLA fibres with a high degree of molecular orientation and crystallinity were produced by hot drawing of the melt-spun and solution-sun fibres.
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Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers.
Snjezana Stolnik,Susan E. Dunn,Martin C. Garnett,Martyn C. Davies,Allan G.A. Coombes,D. C. Taylor,M. P. Irving,S. C. Purkiss,T. F. Tadros,Stanley S. Davis,Lisbeth Illum +10 more
TL;DR: The in vivo results reveal that coating of PLGA nanospheres with PLA:PEG copolymers can alter the biodistribution in comparison to uncoated PLGA Nanospheres and may suggest a different stability of the adsorbed layers on these two systems.
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Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages
TL;DR: The relative phagocytic uptake was found to decrease with increasing adsorbed layer thickness i.e. longer hydrophilic polymer chains of the coating agent and consequently a greater steric stabilization effect.