Journal ArticleDOI
Long circulating microparticulate drug carriers
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TLDR
This review focuses on the physicochemical and biological properties of polymeric particulate carriers in the nanometre size range surface modified by poly(ethylene oxide) (PEO).About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1995-09-01. It has received 706 citations till now. The article focuses on the topics: Drug carrier.read more
Citations
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Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta,Mona Gupta +1 more
TL;DR: This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications.
Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal ArticleDOI
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Biodegradable polymeric nanoparticles based drug delivery systems
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
TL;DR: The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity.
Book
Poly(ethylene glycol) chemistry : biotechnical and biomedical applications
TL;DR: PEG Derivatized Ligands with Hydrophobic and Immunological Specificity and Preparation and Properties of Monomethoxypoly(Ethylene Glycol)Modified Enzymes for Therapeutic Applications.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Polymers at Interfaces
TL;DR: Theoretical methods for polymers at interfaces are described in this article, where the authors show that polymers in solution can be represented by homopolymer adsorption and polyelectrolyte adorption.
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