The Combination of a Tumor Necrosis Factor Inhibitor and Antibiotic Alleviates Staphylococcal Arthritis and Sepsis in Mice
Ying Fei,Wanzhong Wang,Jakub Kwiecinski,Elisabet Josefsson,Rille Pullerits,Ing-Marie Jonsson,Mattias Magnusson,Tao Jin +7 more
TLDR
Treatment with the combination of a TNF inhibitor and an antibiotic resulted in a quicker relief of clinical arthritis in mice with septic arthritis, and it was demonstrated that anti-TNF treatment downregulates high-mobility group protein B1 in staphylococcal enterotoxin shock syndrome.Abstract:
Background. Despite advances in medical practices, in recent decades permanent reductions in joint function have not been achieved, and the high mortality rate of patients with staphylococcal septi ...read more
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HMGB1 in Health and Disease
Rui Kang,Ruochan Chen,Qiuhong Zhang,Wen Hou,Sha Wu,Lizhi Cao,Jin Huang,Yan Yu,Xue Gong Fan,Zhengwen Yan,Zhengwen Yan,Xiaofang Sun,Haichao Wang,Qingde Wang,Allan Tsung,Timothy R. Billiar,Herbert J. Zeh,Michael T. Lotze,Daolin Tang +18 more
TL;DR: High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside thecell as the prototypic damage associated molecular pattern molecule (DAMP).
Journal ArticleDOI
Emu oil based nano-emulgel for topical delivery of curcumin.
Manish Kumar Jeengar,Sri Vishnu Kiran Rompicharla,Shweta Shrivastava,Naveen Chella,Nalini R. Shastri,Vegi Ganga Modi Naidu,Ramakrishna Sistla +6 more
TL;DR: Arthritic scoring, paw volume, biochemical, molecular, radiological and histological examinations indicated significant improvement in anti-inflammatory activity with formulations containing curcumin in combination with emu oil compared to pureCurcumin.
Journal ArticleDOI
Sepsis: in search of cure
Chikkamenahalli Lakshminarayana Lakshmikanth,Shancy Petsel Jacob,Vyala Hanumanthareddy Chaithra,Hugo C. Castro-Faria-Neto,Gopal K. Marathe +4 more
TL;DR: Inability to recognize a single critical mediator of sepsis may be the underlying cause for the poor therapeutic intervention of septicaemia.
Journal ArticleDOI
Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis
TL;DR: The findings offer a unique model to study the role of LITAF in systemic and chronic local inflammatory processes, and pave the way for anti-LITAF therapeutic approaches for the treatment of TNF-mediated inflammatory diseases.
Journal ArticleDOI
Shedding of tumor necrosis factor receptor 1 induced by protein A decreases tumor necrosis factor alpha availability and inflammation during systemic Staphylococcus aureus infection.
Constanza Giai,Cintia Daniela Gonzalez,Camila Ledo,Ailin Natalia Garofalo,Maria Silvia Di Genaro,Daniel O. Sordelli,Marisa Ines Gomez +6 more
TL;DR: The results obtained using a protein A-deficient mutant and tnfr1 −/− mice strongly suggest that the increased levels of soluble TNFR1 present during experimental S. aureus infection may neutralize circulating TNF-α and impair the host inflammatory response.
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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang,Ona Bloom,Minghuang Zhang,Jaideep M. Vishnubhakat,Michael Ombrellino,Jiantu Che,Asia Frazier,Huan Yang,Svetlana Ivanova,Lyudmila V. Borovikova,Kirk R. Manogue,Eugen Faist,Edward Abraham,Jan Andersson,Ulf Andersson,Patricia E. Molina,Naji N. Abumrad,Andrew E. Sama,Kevin J. Tracey +18 more
TL;DR: High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
Journal ArticleDOI
Role of cytokines in rheumatoid arthritis
TL;DR: Overall these studies demonstrate that analysis of cytokine expression and regulation may yield effective therapeutic targets in inflammatory disease.
Journal ArticleDOI
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal.
Michael T. Lotze,Kevin J. Tracey +1 more
TL;DR: These features of HMGB1 are discussed and recent advances that have led to the preclinical development of therapeutics that modulateHMGB1 release and activity are summarized.
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Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
Charles J. Fisher,Jan M. Agosti,Steven M. Opal,Stephen F. Lowry,Robert A. Balk,Jerald C. Sadoff,Edward Abraham,Roland M. H. Schein,Ernest Benjamin +8 more
TL;DR: In patients with septic shock, treatment with the TNFR:Fc fusion protein does not reduce mortality, and higher doses appear to be associated with increased mortality.
Journal ArticleDOI
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Huan Yang,Mahendar Ochani,Jianhua Li,Xiaoling Qiang,Mahira Tanovic,Helena Erlandsson Harris,Srinivas M. Susarla,Luis Ulloa,Hong Wang,Robert DiRaimo,Christopher J. Czura,Haichao Wang,Jesse Roth,H. Shaw Warren,Mitchell P. Fink,Matthew J. Fenton,Ulf Andersson,Kevin J. Tracey +17 more
TL;DR: Observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating thatHMGB1 inhibitors can be administered in a clinically relevant time frame.