Journal ArticleDOI
The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance
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TLDR
In this paper , the conformational status of four resistance associated mutations within the regulatory gamma specific array (γSA) of PLCγ was assessed and two distinct modes of mutation induced activation were revealed by this panel of Ibrutinib resistance mutations.About:
This article is published in Journal of Molecular Biology.The article was published on 2022-03-01. It has received 3 citations till now. The article focuses on the topics: Bruton's tyrosine kinase & Ibrutinib.read more
Citations
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Journal ArticleDOI
Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme
TL;DR: This work provides direct evidence that PLCγ1 is inhibited through obstruction of its membrane-binding surfaces by the regulatory region and that activation must shift P LCγ1 to a conformation competent for membrane binding.
Journal ArticleDOI
Platelets and tyrosine kinase inhibitors: clinical features, mechanism of action and effects on physiology.
Tony J. Zheng,Iván Parra-Izquierdo,Stéphanie E. Reitsma,Michael Heinrich,Mark K. Larson,Joseph J. Shatzel,Joseph E. Aslan,Owen J. T. McCarty +7 more
TL;DR: This review highlights current advances and knowledge on the effects of select TKIs on platelet biology and furthers insight on signaling pathways that may represent novel druggable targets coupled to specific platelet functional responses.
Journal ArticleDOI
Conformational switches that control the TEC kinase – PLCγ signaling axis
TL;DR: In this article , the TEC kinases and PLCγ transition between autoinhibited state and active conformation, and the authors focus on the kinase/phospholipase axis in T-cells and B-cells.
References
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Journal ArticleDOI
The PRIDE database and related tools and resources in 2019: improving support for quantification data.
Yasset Perez-Riverol,Attila Csordas,Jingwen Bai,Manuel Bernal-Llinares,Suresh Hewapathirana,Deepti J. Kundu,Avinash Inuganti,Johannes Griss,Johannes Griss,Gerhard Mayer,Martin Eisenacher,Enrique Perez,Julian Uszkoreit,Julianus Pfeuffer,Timo Sachsenberg,Şule Yılmaz,Shivani Tiwary,Juergen Cox,Enrique Audain,Mathias Walzer,Andrew F. Jarnuczak,Tobias Ternent,Alvis Brazma,Juan Antonio Vizcaíno +23 more
TL;DR: Key statistics on the current data contents and volume of downloads are outlined, and how PRIDE data are starting to be disseminated to added-value resources including Ensembl, UniProt and Expression Atlas are outlined.
Journal ArticleDOI
NMR View: A computer program for the visualization and analysis of NMR data.
TL;DR: NMR View provides structure analysis features and data transfer to and from structure generation programs, allowing for a tight coupling between spectral analysis and structure generation.
Journal ArticleDOI
Regulation of phosphoinositide-specific phospholipase C
TL;DR: The activation and deactivation of each PLC isoform are likely highly regulated processes and are susceptible to different modes of activation.
Journal ArticleDOI
Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
Jennifer A. Woyach,Richard R. Furman,Ta-Ming Liu,Hatice Gulcin Ozer,Marc Zapatka,Amy S. Ruppert,Ling Xue,Daniel Hsieh Hsin Li,Susanne M. Steggerda,Matthias Versele,Sandeep S. Dave,Jenny Zhang,Ayse Selen Yilmaz,Samantha Jaglowski,Kristie A. Blum,Arletta Lozanski,Gerard Lozanski,Danelle F. James,Jacqueline C. Barrientos,Peter Lichter,Stephan Stilgenbauer,Joseph J. Buggy,Betty Y. Chang,Amy J. Johnson,John C. Byrd +24 more
TL;DR: Functional analysis showed that the C481S mutation of BTK results in a protein that is only reversibly inhibited by ibrutinib, which underscores the importance of the B-cell-receptor pathway in the mechanism of action of ibrUTinib in CLL.
Journal ArticleDOI
Hydrogen exchange mass spectrometry for the analysis of protein dynamics.
Thomas E. Wales,John R. Engen +1 more
TL;DR: The general principles of the hydrogen exchange coupled to mass spectrometry method are summarized, the latest variations on the experimental protocol that probe different types of protein movements are discussed, and other recent work and improvements in the field are reviewed.
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