Journal ArticleDOI
The dissociation between aminoglycoside serum concentrations and nephrotoxicity.
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TLDR
The data indicate that high aminoglycoside serum concentrations are not causing nephrotoxicity but rather reflect secondary body accumulation of the drug associated renal damage.About:
This article is published in Life Sciences.The article was published on 1988-01-01. It has received 18 citations till now. The article focuses on the topics: Nephrotoxicity & Renal cortex.read more
Citations
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Journal ArticleDOI
Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study.
Leonard Leibovici,Michal Paul,Oded Poznanski,Moshe Drucker,Zmira Samra,Hanna Konigsberger,Silvio Pitlik +6 more
TL;DR: Combination treatment showed no advantage over treatment with an appropriate beta-lactam drug in nonneutropenic patients with gram-negative bacteremia, both on stratified and on multivariable logistic regression analyses.
Journal ArticleDOI
Limited predictability of amikacin clearance in extreme premature neonates at birth.
TL;DR: Size and post-conception age are the major contributors to clearance variability in extreme premature neonates (<31 weeks PCA) and the large unexplained variability in clearance reinforces the need for target concentration intervention to reduce variability in exposure to a safe and effective range.
Journal ArticleDOI
Pathogenic factors in aminoglycoside-induced nephrotoxicity.
Sam Kacew,Michel G. Bergeron +1 more
TL;DR: The role of infection (pyelonephritis and septicemia) and bacterial endotoxin as pathogenic factors involved in aminoglycoside nephrotoxicity are focused on.
Journal ArticleDOI
Formation of a cytotoxic metabolite from gentamicin by liver
May Y. Huang,Jochen Schacht +1 more
TL;DR: Using isolated cochlear outer hair cells in a recently developed cytotoxicity assay to test the toxicity of aminoglycosides after incubation with drug-metabolizing hepatic enzymes indicates involvement of oxidative metabolism in the formation of the toxic metabolite.
Journal ArticleDOI
Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life
Karel Allegaert,Veerle Cossey,Jean Paul Langhendries,Gunnar Naulaers,Christine Vanhole,Hugo Devlieger,B Van Overmeire +6 more
TL;DR: It is concluded that the time interval between consecutive amikacin administrations should be prolonged, if ibuprofen-lysine is co-administered.
References
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Tay-Sachs Disease: Generalized Absence of a Beta-D-N-Acetylhexosaminidase Component
Shintaro Okada,John S. O'Brien +1 more
TL;DR: Two hexosaminidase components, separable by starch-gel electrophoresis and possessing both β-D-N-acetylglucosamininidase and β-O-NacetylgalactosaminIDase activity, are present in human tissues.
Journal ArticleDOI
The nephrotoxicity of antimicrobial agents (second of three parts).
Gerald B. Appel,Harold C. Neu +1 more
TL;DR: It is necessary to select an antibiotic to use in the treatment of an infection based on benefittoxicity ratios, particularly in critically ill patients with marginal renal function and potentially leukaemia.
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Gentamicin Blood Levels: a Guide to Nephrotoxicity
TL;DR: Valentamicin blood levels may be useful for predicting accumulation of gentamicin which in turn may be correlated with early renal impairment before potentially toxic serum levels of Gentamicin develop.
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The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue.
TL;DR: The most highly purified enzyme preparations catalyzed the hydrolysis of sphingomyelin, whereas lecithin and phosphatidylethanolamine were unaffected and the products of the reaction were identified as phosphorylcholine and ceramide.
Journal ArticleDOI
Rat-kidney lysosomes: isolation and properties
S. Shibko,A.L. Tappel +1 more
TL;DR: The latent nature of the alpha-glucosidase and lysozyme of intact kidney lysosomes was demonstrated by their graded and parallel release with other typical lysOSomal enzymes.