The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein-protein interaction.
Quanhui Zheng,Yong Zhao +1 more
TLDR
The LIM domain is a cysteine‐ and histidine‐rich motif that has been proposed to direct protein—protein interactions and displays various functions including gene regulation and cell fate determination, tumour formation and cytoskeleton organization.About:
This article is published in Biology of the Cell.The article was published on 2007-09-01 and is currently open access. It has received 159 citations till now. The article focuses on the topics: LHX3 & LIM domain.read more
Citations
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Homeodomain proteins: an update.
TL;DR: An update of the review on homeobox genes that was written together with Walter Gehring in 1994 is provided, using the 103 Drosophila homeOBox genes as example, and an updated classification is presented.
Journal ArticleDOI
Endothelial Barrier and Its Abnormalities in Cardiovascular Disease
Dimitry A. Chistiakov,Alexander N. Orekhov,Alexander N. Orekhov,Yuri V. Bobryshev,Yuri V. Bobryshev +4 more
TL;DR: chemical modification of tubulin caused by cardiometabolic risk factors and oxidative stress leads to reorganization of endothelial microtubules, which destabilize vascular integrity and increase permeability, which finally results in increasing cardiovascular risk.
Journal ArticleDOI
The Dual Functions of WLIM1a in Cell Elongation and Secondary Wall Formation in Developing Cotton Fibers
Li-Bo Han,Yuan-Bao Li,Hai-Yun Wang,Xiaomin Wu,Chun-Li Li,Ming Luo,Shen-Jie Wu,Zhaosheng Kong,Yan Pei,Gai-Li Jiao,Gui-Xian Xia +10 more
TL;DR: It is demonstrated that WLIM1a has dual roles in cotton fiber development, elongation, and secondary wall formation and that lignin/lignin-like phenolics may substantially affect cotton fiber quality; this finding may guide cotton breeding for improved fiber traits.
Journal ArticleDOI
Transcriptional regulation of hepatic stellate cells.
Jelena Mann,Derek A. Mann +1 more
TL;DR: Current knowledge of the transcription factors that either control HSC activation or which regulate specific fibrogenic functions of the activated HSC such as collagen expression, proliferation and resistance to apoptosis are surveyed.
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ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin.
Abbas Agaimy,Katharina Erlenbach-Wünsch,Björn Konukiewitz,Anja Schmitt,Ralf J. Rieker,Michael Vieth,Franklin Kiesewetter,Arndt Hartmann,Giuseppe Zamboni,Aurel Perren,Günter Klöppel +10 more
TL;DR: The results show the almost ubiquitous expression of ISL1 in extrapancreatic poorly differentiated neuroendocrine neoplasms and neuroblastic malignancies and its common loss in pancreatic well and poorly differentiated Neoplasms.
References
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Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
TL;DR: It is demonstrated that stimulation of fibroblasts with lysophosphatidic acid, which activates rho, induces myosin light chain phosphorylation, which precedes the formation of stress fibers and focal adhesions and is accompanied by increased contractility.
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Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Midori Maekawa,Toshimasa Ishizaki,Shuken Boku,Naoki Watanabe,Akiko Fujita,Akihiro Iwamatsu,Takashi Obinata,Kazumasa Ohashi,Kensaku Mizuno,Shuh Narumiya +9 more
TL;DR: Results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylated of cofilin by LIM- Kinase contribute to Rho-induced reorganization of the actin cytoskeleton.
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Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart
Chen-Leng Cai,Xingqun Liang,Yunqing Shi,Po Hsien Chu,Samuel L. Pfaff,Ju Chen,Sylvia M. Evans +6 more
TL;DR: Two sets of cardiogenic precursors are defined, one of which expresses and requires Isl1 and the other of which does not, which have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells.
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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
TL;DR: It is shown that p21-activated kinase (Pak1) phosphorylates LIM-kinase at threonine residue 508 within LIM- Kinase’s activation loop, and increases LIM-Kinase-mediated phosphorylation of the actin-regulatory protein cofilin tenfold in vitro.
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The LIM domain: from the cytoskeleton to the nucleus
TL;DR: First described 15 years ago as a cysteine-rich sequence that was common to a small group of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc-finger structure that functions as a modular protein-binding interface.