The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application.
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The results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoInitiators.Abstract:
Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.read more
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Photopolymerization of Polymeric Composites in Drug Delivery, Tissue Engineering, and Other Biomedical Applications
TL;DR: The present chapter aimed at providing an in-depth discussion on the latest advances in the utilization of photopolymerization technology in the drug delivery and tissue engineering fields with emphasis on the principles of photoirradiation and photopolyMERization technology, common precursors, compatibility of photoinitiators, and their potential pharmaceutical and biomedical applications.
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Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase
Ali Mohammed,Juan Aviles Milan,Siwei Li,Justin J. Chung,Molly M. Stevens,Theoni K. Georgiou,Julian R. Jones +6 more
TL;DR: Use of the enzyme glucose oxidase (GOx) allowed open vessel free radical photopolymerization (FRP) of PAAm and PAMPS and enabled double network hydrogels with good mechanical properties.
References
More filters
Journal ArticleDOI
Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
Journal ArticleDOI
TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
AKT/PKB signaling: navigating downstream.
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
Journal ArticleDOI
Modulation of oxidative stress as an anticancer strategy.
TL;DR: The controversial role of ROS in tumour development and in responses to anticancer therapies is addressed, and the idea that targeting the antioxidant capacity of tumour cells can have a positive therapeutic impact is elaborate.