The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription
Natalie von der Lehr,Sara Johansson,Siqin Wu,Fuad Bahram,Alina Castell,Cihan Cetinkaya,Per Hydbring,Ingrid Weidung,Keiko Nakayama,Keiichi I. Nakayama,Ola Söderberg,Tom K. Kerppola,Lars-Gunnar Larsson +12 more
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TLDR
The results suggest that Skp2 is a transcriptional cofactor for c-Myc and indicates a close relationship between transcription activation and transcription factor ubiquitination.About:
This article is published in Molecular Cell.The article was published on 2003-05-01 and is currently open access. It has received 466 citations till now. The article focuses on the topics: E-box & Response element.read more
Citations
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Function and regulation of cullin-RING ubiquitin ligases.
TL;DR: This review focuses on the composition, regulation and function of cullin–RING ligases, and describes how these enzymes can be characterized by a set of general principles.
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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
Raimond B. G. Ravelli,Benoît Gigant,Patrick A. Curmi,Isabelle Jourdain,Sylvie Lachkar,André Sobel,Marcel Knossow +6 more
TL;DR: Changes in the subunits of tubulin as it switches from its straight conformation to a curved one correlate with the loss of lateral contacts and provide a rationale for the rapid microtubule depolymerization characteristic of dynamic instability.
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Ubiquitin ligases: cell-cycle control and cancer
TL;DR: A better understanding of the ubiquitylation machinery will provide new insights into the regulatory biology of cell-cycle transitions and the development of anti-cancer drugs.
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Transcriptional regulation and transformation by Myc proteins
Sovana Adhikary,Martin Eilers +1 more
TL;DR: A wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.
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Myc's broad reach.
Martin Eilers,Robert N. Eisenman +1 more
TL;DR: The nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology are reviewed.
References
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Journal ArticleDOI
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
TL;DR: 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
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The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
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Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation
TL;DR: Results attest to the general applicability of the BiFC assay for studies of protein interactions.
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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
TL;DR: It is shown that the F-box protein SKP2 specifically recognizes p27 in a phosphorylation-dependent manner that is characteristic of an F- box-protein–substrate interaction and is subject to dual control by the accumulation of bothSKP2 and cyclins following mitogenic stimulation.
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Themes and variations on ubiquitylation.
TL;DR: It is shown that the conjugation of proteins with a small protein called ubiquitin touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer.