Journal ArticleDOI
The genetical structure of populations
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This article is published in Annals of Human Genetics.The article was published on 1949-01-01. It has received 6139 citations till now. The article focuses on the topics: Population.read more
Citations
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Journal ArticleDOI
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
Tim Downing,Hideo Imamura,Saskia Decuypere,Taane G. Clark,Graham H. Coombs,James Cotton,James D. Hilley,Simonne De Doncker,Ilse Maes,Jeremy C. Mottram,Michael A. Quail,Suman Rijal,Mandy Sanders,Gabriele Schönian,Olivia Stark,Shyam Sundar,Manu Vanaerschot,Christiane Hertz-Fowler,Jean-Claude Dujardin,Matthew Berriman +19 more
TL;DR: It is shown that whole-genome sequence data reveals genetic structure within these lines not shown by multilocus typing, and suggests that drug resistance has emerged multiple times in this closely related set of lines, providing additional power to track the drug resistance and epidemiology of an important human pathogen.
Journal ArticleDOI
Estimating recombination rates from population genetic data.
Paul Fearnhead,Peter Donnelly +1 more
TL;DR: A new method for estimating recombination rates from population genetic data using a computationally intensive statistical procedure (importance sampling) to calculate the likelihood under a coalescent-based model is introduced.
Journal ArticleDOI
Population structure and speciation in tropical seas: global phylogeography of the sea urchin diadema
TL;DR: The phylogeny of the pantropical and subtropical sea urchin genus Diadema is reconstructed, using sequences of mitochondrial DNA from 482 individuals collected around the world, to determine the efficacy of barriers to gene flow and to ascertain the history of possible dispersal and vicariance events that led to speciation.
Book ChapterDOI
The Genetics of Inbreeding Populations
TL;DR: This chapter discusses the effects of inbreeding in terms of genetic models of steadily increasing complexity with observations and measurements that show that inbreeding populations contain large amounts of genetic variability and that this variability is organized into highly integrated and flexible systems.
Journal ArticleDOI
Q ST – F ST comparisons: evolutionary and ecological insights from genomic heterogeneity
TL;DR: Comparative studies of the divergence of quantitative traits and neutral molecular markers, known as QST–FST comparisons, provide a means for researchers to distinguish between natural selection and genetic drift as causes of population differentiation in complex polygenic traits.
References
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Journal ArticleDOI
Evolution in Mendelian Populations.
TL;DR: Page 108, last line of text, for "P/P″" read "P′/ P″."
Journal ArticleDOI
Coefficients of Inbreeding and Relationship
TL;DR: The importance of having a coefficient by means of which the degree of inbreeding may be expressed has been brought out by Pearl' in a number of papers published between 1913 and 1917.
Book
The material basis of evolution.
TL;DR: Goldschmidt as discussed by the authors argued that macroevolution resulted from larger jumps in genotype across "bridgeless gaps" related either to systemic mutations or to mutations affecting early development.
Related Papers (5)
Estimating F-statistics for the analysis of population structure.
Bruce S. Weir,C. Clark Cockerham +1 more