The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine
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TLDR
The commensal lifestyle of C. albicans in the intestine, the role of morphology for Commensalism, the influence of diet, and the interactions with bacteria of the microbiota are discussed.About:
This article is published in Current Opinion in Microbiology.The article was published on 2020-08-01 and is currently open access. It has received 69 citations till now. The article focuses on the topics: Candida albicans & Systemic candidiasis.read more
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A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors
Anders B. Dohlman,Jared Klug,Marissa Mesko,Iris H. Gao,Steven M. Lipkin,Xiling Shen,Iliyan D. Iliev +6 more
TL;DR: In this paper , the authors showed that the presence of Candida in human GI tumors was confirmed by external ITS sequencing of tumor samples and by culture-dependent analysis in an independent cohort, suggesting that tumor-associated fungal DNA may serve as diagnostic or prognostic biomarkers.
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The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis
TL;DR: The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in glucose degradation in most living cells as mentioned in this paper, and it has a unidirectional oxidative part with glucose-6-phosphate dehydrogenase as a key enzyme generating NADPH, and a non-oxidative part involving the reversible transketolase and transaldolase reactions, which interchange PPP metabolites with gly colysis.
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Diagnosis and Treatment of Invasive Candidiasis
TL;DR: Therapeutic options for invasive candidiasis are generally limited to four classes of systemic antifungals (polyenes, antimetabolite 5-fluorocytosine, azoles, echinocandins) with the two latter being highly effective and well-tolerated and hence the most widely used.
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I want to break free - macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape.
TL;DR: This review focuses on the most recent insights into the strategies of macrophages to eliminate C. albicans and the fungal counterstrategies to overcome these threats.
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Fungal microbiome in inflammatory bowel disease: a critical assessment
TL;DR: In the context of inflammatory bowel disease (IBD) pathogenesis and disease activity, recent advances have provided tools for the study of host genetics and metagenomics of host-fungal interaction as mentioned in this paper .
References
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Candida albicans pathogenicity mechanisms
TL;DR: This review presents an update on the current understanding of the pathogenicity mechanisms of this important human pathogen and reveals novel virulence mechanisms have recently been discovered.
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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
Iliyan D. Iliev,Vincent Funari,Vincent Funari,Kent D. Taylor,Quoclinh Nguyen,Christopher N. Reyes,Samuel P. Strom,Jordan Brown,Courtney A. Becker,Phillip Fleshner,Marla Dubinsky,Jerome I. Rotter,Hanlin L. Wang,Dermot P.B. McGovern,Gordon D. Brown,David M. Underhill,David M. Underhill +16 more
TL;DR: It is shown that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1, which substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.
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The gut mycobiome of the Human Microbiome Project healthy cohort
Andrea K. Nash,Thomas A. Auchtung,Matthew C. Wong,Daniel P. Smith,Jonathan R. Gesell,Matthew C. Ross,Christopher J. Stewart,Ginger A. Metcalf,Donna M. Muzny,Richard A. Gibbs,Nadim J. Ajami,Joseph F. Petrosino +11 more
TL;DR: The gut mycobiome of the Human Microbiome Project (HMP) cohort was investigated by sequencing the Internal Transcribed Spacer 2 (ITS2) region as well as the 18S rRNA gene, suggesting that it is a more sensitive method for studying the mycoboome of stool samples.
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The mycobiota: interactions between commensal fungi and the host immune system.
TL;DR: What is currently known about the makeup of fungal communities in the body and the features of the immune system that are particularly important for interacting with fungi at these sites are discussed.
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Revisiting the Source of Candidemia: Skin or Gut?
Marcio Nucci,Elias Anaissie +1 more
TL;DR: It is suggested that the gut is an important source of candidemia, and studies that supported the skin as a source for this infection were surprisingly incomplete.