The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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Cardiac Complications in Non-Transfusion Dependent Thalassaemia
TL;DR: This review discusses haemoglobinopathies in general, followed by pathogenesis, clinical features and management of cardiac complications.
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Molecular spectrum and distribution of hemoglobinopathies in southwest of Iran: a seven-year retrospective study
TL;DR: The findings showed that the distribution of beta thalassemia mutations differs from other previous data reported from Khuzestan and other provinces, and is useful for screening and preventing thalasemia.
Journal Article
Isolation and Purification of Acetylcolinesterases (AchE ) from Blood of Thalassimic Patient and Kinetic Studies for Purified Enzyme
TL;DR: The kinetics of the enzyme were studied and the results showed that the maximum velocity was 7.8 µmol/min/mol and the K m was 0.1 M, which indicates that AchE has an approximat molecular weight of 173720 Dalton.
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First observation of hemoglobin G-Norfolk in the Turkish population
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Prevalence and Genetic Analysis of β-Thalassemia in the Dali Bai Autonomous Prefecture of the Yunnan Province, China.
Xiao-Xuan Wang,Yuan-Yuan Ma,Wei Zheng Zhang,Jia-Yao Liu,Liang-ping Su,Hui Su,xiaolong lin,Jinson Yuan,Yan Chun Wang,Yun-Chun Liu,Ming-Ming Lai +10 more
TL;DR: The data suggests that the Dali Autonomous Prefecture of Yunnan Province is an area with a high prevalence of β-thalassemia, and the results showed that the prevalence of CD26 mutations was significantly higher than that of the other mutations.
References
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Journal ArticleDOI
Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.