The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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The Outcomes of Allogenic Bone Marrow Transplantation for BThalassemia Major Patients: Single-Centre Experience
TL;DR: In this paper , the outcome of allogenic bone marrow transplantation for B-Thalassemia Major (B-TM) patients at KFSHD was assessed and compared with international outcomes, and the complications of this modality of treatment in our cohort.
Machine learning base sickle disease prediction and recommendation system
TL;DR: This work has proposed ensemble method as collection of classifiers which will return prediction result which will have highest accuracy in order to improve accuracy of prediction result.
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RS12574989 and haplotype associated with α/β-chain imbalance and population HbA2 reduction
TL;DR: In this paper , the authors focused on individuals with normal red blood cell indices and no common thalassemia pathogenic mutation and selected three groups for the following study: the control group (2.5% ≤ HbA 2 ≤ 3.5%), the Hb A 2 under 2.5 group (Hb A2 < 2.4%), and the hb A 3 under 2 .4 group.
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The role of molecular diagnostic testing for hemoglobinopathies and thalassemias
TL;DR: In this paper , the authors proposed that the expertise available in the clinical hematology laboratory is essential for the diagnosis of patients with hemoglobin abnormalities, and that molecular diagnosis is helpful in cases where the diagnosis is uncertain and for genetic counseling.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.