The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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Serum zinc status in thalassemic adolescents attending Yangon Children Hospital, Myanmar
TL;DR: In spite of zinc supplementation, nearly 70% of the thalassemic adolescents showed zinc deficiency, which might not be related to gender, phenotypes or the use of chelator.
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Immunology and Systemic Inflammation Biomarkers Among Saudi Patients with Sickle Cell Anemia in Asymptomatic Steady State Condition
TL;DR: Sickle cell anemia is an incurable chronic medical problem with homozygous for hemoglobin S (HbS) that induce tissue ischemia and infarction due to vascular occlusion that initiates inflammatory responses.
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No Evidence for Role of Common Anion Exchanger 1 Mutations on the Severity Difference in HB E-β-Thalassemia Disease in Northeast Thailand
Lalitpatch Ngouprommin,Nattaya Sae-ung,Supan Fucharoen,Goonnapa Fucharoen,Kanokwan Sanchaisuriya,Arunee Jetsrisuparb +5 more
TL;DR: The result indicates that AE1 mutation is rare and should not be an important phenotypic modifier in the Hb E-β-thalassemia disease, and screening of common AE1 mutations in thalassemia patient is not necessary.
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Hemoglobin disorders in the developing world: a perspective from Sri Lanka.
TL;DR: To the editor: Lakshman Perera gestured for the middle-aged woman and her preadolescent daughter to come over to the table and requested in Sinhalese that they please sit down, as he himself took a seat on the opposite side and examined the paperwork that he had been handed.
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Usefulness of chorionic villus sampling for prenatal diagnosis of thalassaemia: a clinical study in eastern India -
TL;DR: This retrospective study reviewed the pregnancy outcome of 362 patients with thalassaemia who underwent transabdominal chorionic villus sampling between 10-13 weeks of gestation for prenatal diagnosis to provide local data for counseling the prospective parents in similar situation.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.