The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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Recent trends in treatment of thalassemia
TL;DR: An overview of emerging recent trends in treatment of thalassemia targeting IE, iron dysregulation and novel curative treatments as gene therapy and gene editing is provided.
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ATG vs thiotepa with busulfan and cyclophosphamide in matched-related bone marrow transplantation for thalassemia
Lawrence Faulkner,Cornelio Uderzo,Sadaf Khalid,Priya Marwah,Rajpreet Soni,Naila Yaqub,Samina Amanat,Itrat Fatima,Sarah Khan Gilani,Tatheer Zahra,Stalin Ramprakash,Lallindra Gooneratne,Ruwangi Dissanayake,Senani Williams,Wasantha Rathnayake,Reshma Srinivas,Amit Sedai,Ankita Kumari,Lailith Parmar,Rakesh Dhanya,Rajat Kumar Agarwal +20 more
TL;DR: Comparing matched-related BMT outcomes in 2 groups of low-risk ST patients conditioned with either Tt or anti-thymocyte globulin (ATG) in addition to BuCy suggests Substituting Tt with ATG in the standard BuCy context seems safe and effective and may decrease transplant-related mortality.
Journal ArticleDOI
Current status of beta-thalassemia and its treatment strategies.
Shaukat Ali,Shumaila Mumtaz,Hafiz Abdullah Shakir,Muhammad Tahir Khan,Hafiz Muhammad Tahir,Samaira Mumtaz,Tafail Akbar Mughal,Ali Hassan,Syed Akif Raza Kazmi,Muhammad Irfan,Muhammad Adeeb Khan +10 more
TL;DR: In this article, an inherited hematological disorder called thalassemia major, intermedia, and minor/silent carrier has been classified into three main forms: (1) the absence or reduced amount of beta-globin chains causes ineffective erythropoiesis, which leads to anemia, (2) a more severe form among these is thalassmia major in which individuals depend upon blood transfusion for survival, and (3) the intermediate is symptomatic; however; it can also be accomplished by folic supplementation and splenectomy.
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In vivo activation of the human δ-globin gene: the therapeutic potential in β-thalassemic mice
Maria Francesca Manchinu,Maria F. Marongiu,Daniela Poddie,Carla Casu,Veronica Latini,Michela Simbula,Renzo Galanello,Paolo Moi,Antonio Cao,Susanna Porcu,Maria Serafina Ristaldi +10 more
TL;DR: The human δ-globin gene can be activated in vivo in a stage- and tissue-specific fashion simply by the insertion of a Kruppel-like factor 1 binding site into the promoter, and gives rise to a robust increase of the hemoglobin level in β-thalassemic mice.
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Morbidities in non-transfusion-dependent thalassemia.
Antoine N. Saliba,Ali T. Taher +1 more
TL;DR: The treatment of NTDT relies on occasional or more frequent blood transfusions for certain indications, iron chelation therapy, splenectomy, and hydroxyurea, and sheds light on future therapeutic directions in the field.
References
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Journal ArticleDOI
Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
Journal ArticleDOI
Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
Journal ArticleDOI
The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.