The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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Journal ArticleDOI
Knowledge insufficient: the management of haemoglobin SC disease
TL;DR: Clinical and translational research is needed to develop targeted treatments and to validate management recommendations for efficacy, safety and impact on quality of life for people with HbSC.
Journal ArticleDOI
A Melting Curve Analysis–Based PCR Assay for One-Step Genotyping of β-Thalassemia Mutations: A Multicenter Validation
Fu Xiong,Qiuying Huang,Xiaoyun Chen,Yu-Qiu Zhou,Xinhua Zhang,Ren Cai,Yajun Chen,Jiansheng Xie,Shanwei Feng,Xiaofeng Wei,Qi-zhi Xiao,Tianlang Zhang,Shiqiang Luo,Xuehuang Yang,Ying Hao,Yanxia Qu,Qingge Li,Xiangmin Xu +17 more
TL;DR: It was concluded that the MeltPro HBB assay is useful for reliable genotyping of multiple β-thalassemia mutations in clinical settings and may have potential as a versatile method for rapid genotypes of known mutations because of its high throughput, accuracy, ease of use, and low cost.
Book ChapterDOI
Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease.
TL;DR: Identification of the genetic variants modifying HbF production in combination with α-globin genotype provide some prediction of disease severity for β-thalassemia and SCD but generation of a personalized genetic risk score to inform prognosis and guide management requires a larger panel of genetic modifiers yet to be discovered.
The association between malaria parasitaemia, erythrocyte polymorphisms, malnutrition and anaemia in children less than 10 years in Senegal
TL;DR: A case control study involving children aged from 1 to 10 years was conducted to assess some assumed contributors to anaemia in the area of Bonconto Health post in Senegal as mentioned in this paper.
Journal ArticleDOI
Survival and complication rates in patients with thalassemia major in Taiwan.
Han-Ping Wu,Han-Ping Wu,Cheng-Li Lin,Yin Chen Chang,Kang Hsi Wu,Kang Hsi Wu,Rouh Lih Lei,Ching-Tien Peng,Ching-Tien Peng,Tefu Weng,Yu Man Tai,Yu Hua Chao +11 more
TL;DR: While transfusion and iron chelation therapy for thalassemia major (TM) has improved dramatically in recent years, the consequences of this improvement remain unknown.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
Journal ArticleDOI
Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
Journal ArticleDOI
The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.