The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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How to setup a successful transplant program for hemoglobinopathies in developing countries: The Cure2Children approach.
TL;DR: Improved prevention and early care should proceed in parallel with the development of transplant services and hope for cure, and relatively simple and inexpensive measures such as newborn screening, early diagnosis, caregiver education, and timely institution of anti-pneumococcal prophylaxis and hydroxyurea therapy can substantially reduce SCD-related mortality and morbidity.
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T-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?
TL;DR: This review focuses on the two commonly used approaches for haploidentical hematopoietic transplants, namely T-cell deplete and T- cell replete, each of which is associated with unique benefits and drawbacks.
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Thalassemia and other Hemoglobinopathies in Bangladeshi Children
TL;DR: E-β Thalassemia was found the commonest type of thalassemi among Bangladeshi children and consanguineous marriage was found in 14% parents.
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Is there a role for pharmacogenetics in the treatment of sickle cell disease
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Association between HLA‐DRB1*01 and HLA‐DRB1*15 with alloimmunisation in transfusion‐dependent patients with thalassaemia
TL;DR: There is a significant correlation between HLA-DRB1*15 and Anti-K and anti-E alloantibodies and these findings can be useful in detecting susceptible thalassaemic patients and improving transfusion management.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.