The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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Sickle cell disease in Africa: a neglected cause of early childhood mortality.
Scott D. Grosse,Isaac Odame,Hani K. Atrash,Djesika D. Amendah,Frédéric B. Piel,Thomas N. Williams,Thomas N. Williams +6 more
TL;DR: Although there is enough evidence to justify investments in screening, prophylaxis, and treatment for African children with SCD, better data are needed to estimate the numbers of child deaths preventable by such interventions and their cost effectiveness.
Journal ArticleDOI
Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries
TL;DR: In this paper, the authors outline definitions and classifications of anemia, describe the biological mechanisms through which anemia develops, and review the variety of conditions that contribute to anemia development.
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Control of iron deficiency anemia in low- and middle-income countries
Sant-Rayn Pasricha,Sant-Rayn Pasricha,Hal Drakesmith,Jim Black,David B Hipgrave,Beverley-Ann Biggs,Beverley-Ann Biggs +6 more
TL;DR: This review provides an overview and an approach for the implementation of public health interventions for controlling IDA in low- and middle-income countries, with an emphasis on current evidence-based recommendations.
Journal ArticleDOI
The α-Thalassemias
TL;DR: More than 100 varieties of α-thalassemia have been identified and their geographic distribution and the challenges associated with screening, diagnosis, and management suggest they should have a higher priority on global public health agendas.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.