The inherited diseases of hemoglobin are an emerging global health burden
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TLDR
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries, with the true magnitude of this burden still unknown.About:
This article is published in Blood.The article was published on 2010-06-03 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Global health & Public health.read more
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A roadmap for the standardization of hemoglobin A(2)
TL;DR: Preliminary results are reported concerning the yearly distributions of HbA2, collected in two different locations, and using different analytical methods, and proved that results by capillary electrophoresis in 2 out of the 3 years of observation, were significantly lower than those by HPLC.
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Headache: an important symptom possibly linked to white matter lesions in thalassaemia
Anuja Premawardhena,Udaya K. Ranawaka,Taraka Pilapitiya,Gihan Weerasinghe,A. Hapangama,Shantha Hettiarachchi,Arunasalam Pathmeswaran,K.A. Salvin,Ishari Silva,Nizri Hameed,Mark W Weatherall,Nancy F. Olivieri,David J. Weatherall +12 more
TL;DR: It is found that headaches were more common in thalassaemia patients than in controls and WMCs were not associated with reduction of cognition, but cognition was lower in the TI and EBT groups compared with those with TM.
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Is Skeletal Muscle Dysfunction a Limiting Factor of Exercise Functional Capacity in Patients with Sickle Cell Disease
Etienne Gouraud,Philippe Connes,Alexandra Gauthier-Vasserot,Camille Faes,Salima Merazga,Solène Poutrel,Céline Renoux,Camille Boisson,Philippe Joly,Yves Bertrand,Arnaud Hot,Giovanna Cannas,Christophe Hautier +12 more
TL;DR: In this paper, the authors explored how muscle dysfunction may explain the reduced functional capacity of patients with sickle cell disease (SCD) due to anemia and cardio-respiratory abnormalities.
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An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
Clement Opoku-Okrah,Clement Opoku-Okrah,Michael P. Gordge,E. Kweku Nakua,T. Abgenyega,M. Parry,Claire E. Robertson,Caroline L. Smith +7 more
TL;DR: The impact of alpha+‐thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana is investigated.
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Building partnerships to target sickle cell anemia in Africa.
TL;DR: A critical role for north-south partnerships to launch public health and research initiatives in LMICs is highlighted, as well as the effectiveness of a threeway public-private partnership including academia, government, and the private sector.
References
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Sickle cell disease
TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.
Disease control priorities in developing countries.
Dean T. Jamison,Joel G. Breman,Anthony R. Measham,George Alleyne,Mariam Claeson,David B. Evans,Prabhat Jha,Anne Mills,Philip Musgrove +8 more
TL;DR: This first edition provides information on disease control interventions for the most common diseases and injuries in developing countries to help them define essential health service packages and offers preventive and case management guidelines critical to improving the quality of care.
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Global epidemiology of haemoglobin disorders and derived service indicators
TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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The neglected burden of Plasmodium vivax malaria
TL;DR: Feature of the transmission biology of P. vivax give this species greater resilience than the less robust Plasmodiumfalciparum in the face of conditions adverse to the transmission of the parasites, therefore, as control measures become more effective, the residual malaria burden is likely increasingly to become that of Pivax.