Journal ArticleDOI
The Pathogenesis of the Antiphospholipid Syndrome
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TLDR
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies associated with obstetrical complications as well as venous and arterial thrombosis risks.Abstract:
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies. It is associated with obstetrical complications (mainly spontaneous abortion) as well as venous and arterial thrombotic risks. Insights into disease mechanisms have led to new therapies.read more
Citations
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High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.
Julie Helms,Charles Tacquard,François Severac,Ian Leonard-Lorant,Mickaël Ohana,Xavier Delabranche,Hamid Merdji,Raphaël Clere-Jehl,Malika Schenck,Florence Fagot Gandet,Samira Fafi-Kremer,Vincent Castelain,Francis Schneider,Lelia Grunebaum,Eduardo Anglés-Cano,Laurent Sattler,Paul-Michel Mertes,Ferhat Meziani +17 more
TL;DR: Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications, and higher antICOagulation targets than in usual critically ill patients should therefore probably be suggested.
Journal ArticleDOI
Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients
Ricard Cervera,Munther A. Khamashta,Y Shoenfeld,M. T. Camps,Søren Jacobsen,Emese Kiss,Margit Zeher,Angela Tincani,I. Kontopoulou-Griva,Mauro Galeazzi,Francesca Bellisai,Pier Luigi Meroni,R. H. W. M. Derksen,P. G. De Groot,Erika Gromnica-Ihle,Marta Baleva,Marta Mosca,Stefano Bombardieri,Frédéric Houssiau,Jean-Christophe Gris,Isabelle Quéré,Eric Hachulla,Carlos Vasconcelos,B. Roch,Antonio Fernández-Nebro,J.C. Piette,Gerard Espinosa,Silvia Bucciarelli,C. N. Pisoni,Maria Laura Bertolaccini,M. C. Boffa,G. R. V. Hughes +31 more
TL;DR: Patients with APS still develop significant morbidity and mortality despite current treatment, and it is imperative to increase the efforts in determining optimal prognostic markers and therapeutic measures to prevent these complications.
Journal ArticleDOI
Diagnosis and Management of the Antiphospholipid Syndrome.
David A. Garcia,Doruk Erkan +1 more
TL;DR: The immune response to antiphospholipid antibodies can induce endothelial-cell, complement, platelet, neutrophil, and monocyte activation, leading to thrombosis, renal failure, heart valve disea...
Journal ArticleDOI
Haemolytic uraemic syndrome.
TL;DR: A specific mechanism-based treatment has been made available for patients affected by atypical haemolytic uraemic syndrome due to complement dysregulation, but such treatment is, however, still absent for several other disease types, including shiga toxin-induced haemologic syndrome.
Journal ArticleDOI
The role of neutrophils and NETosis in autoimmune and renal diseases
Sarthak Gupta,Mariana J. Kaplan +1 more
TL;DR: In several systemic autoimmune diseases, the imbalance between NET formation and degradation might increase the half-life of these lattices, which could enhance the exposure of the immune system to modified autoantigens and increase the capacity for NET-induced organ damage.
References
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Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients
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