Journal ArticleDOI
The pineal gland and melatonin in relation to aging: a summary of the theories and of the data.
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TLDR
Within recent years, many investigators have implicated the pineal gland and melatonin in the processes of both aging and age-related diseases, with one theory assuming that the waning melatonin cycle provides an important switch for genetically programmed aging at the cellular level.About:
This article is published in Experimental Gerontology.The article was published on 1995-05-01. It has received 283 citations till now. The article focuses on the topics: Melatonin & Pineal gland.read more
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Oxidative stress, aging, and diseases.
Ilaria Liguori,Gennaro Russo,Francesco Curcio,Giulia Bulli,Luisa Aran,David Della-Morte,Gaetano Gargiulo,Gianluca Testa,Gianluca Testa,Francesco Cacciatore,Domenico Bonaduce,Pasquale Abete +11 more
TL;DR: Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions.
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Melatonin in humans.
TL;DR: This review summarizes current knowledge about melatonin in humans and its clinical implications and concludes that there is evidence that melatonin may have a role in the biologic regulation of circadian rhythms, sleep, mood, and perhaps reproduction, tumor growth, and aging.
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Oxidative processes and antioxidative defense mechanisms in the aging brain.
TL;DR: A newly discovered, potentially highly important antioxidant in the brain is the indole melatonin, which is more effective than glutathione in scavenging the highly toxic hydroxyl radical and also more efficient than vitamin E in neutralizing the peroxyl radical.
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A review of the evidence supporting melatonin's role as an antioxidant
Russel J. Reiter,Daniela Melchiorri,Ewa Sewerynek,Burkhard Poeggeler,Lorneli Barlow-Walden,Jih Ing Chuang,Genaro G. Ortiz,Darío Acuña-Castroviejo +7 more
TL;DR: Melatonin is remarkably potent in protecting against free radical damage induced by a variety of means, and DNA damage resulting from either the exposure of animals to the chemical carcinogen safrole or to ionizing radiation is markedly reduced when melatonin is co‐administered.
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
References
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Journal ArticleDOI
The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
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The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
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Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
TL;DR: The pineal gland can be rapidly removed from rodents with minimal damage to adjacent neural structures using a specially designed trephine, and since the mid 1960s, research on the gland has become a very active area of investigation.
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DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems
Barry Halliwell,Okezie I. Aruoma +1 more
TL;DR: Observation of the role of different oxygen‐derived species in DNA cleavage reactions has been used to determine the extent of oxidative damage to DNA in vivo and to investigate the mechanism of DNA damage by ionizing radiation and chemical carcinogens.