Open AccessJournal Article
The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
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This article is published in The Journal of Physiology.The article was published on 1910-01-01 and is currently open access. It has received 2435 citations till now. The article focuses on the topics: Dissociation (chemistry).read more
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Precise detection of pH inside large unilamellar vesicles using membrane-impermeable dendritic porphyrin-based nanoprobes.
Thorn Leiding,Kamil Górecki,Tomas Kjellman,Sergei A. Vinogradov,Cecilia Hägerhäll,Sindra Peterson Årsköld +5 more
TL;DR: The pH-sensitive fluorescent nanoprobe Glu(3), which is well suited for pH measurements in microcompartmentalized biological systems, was found to be completely membrane impermeable, and its distinct spectroscopic features permit pH measurements inside closed membrane vesicles, enabling quantitative mechanistic studies of membrane-spanning proteins.
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Clinical decision support and closed-loop control for intensive care unit sedation
TL;DR: The challenges and opportunities of clinical decision support and closed‐loop control for intensive care unit sedation and the state‐of‐the‐art in active control of drug delivery systems for clinical pharmacology are discussed.
Journal Article
Tasosartan, Enoltasosartan, and Angiotensin II Receptor Blockade: The Confounding Role of Protein Binding
TL;DR: The delayed in vivo blockade effect observed for enoltasosartan appears to be due to a high and tight protein binding and a slow dissociation process from the carrier, while the delayed in vitro blockade effect was markedly influenced by the presence of plasma proteins, leading to a decrease in its affinity for the receptor and a slower receptor association rate.
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Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma.
W. Barchuk,J. Lambert,Rainard Fuhr,J.Z. Jiang,K. Bertelsen,Anne M. Fourie,Xuejun Liu,P.E. Silkoff,Elliot S. Barnathan,Robin L. Thurmond +9 more
TL;DR: JNJ-40929837 substantially inhibited LTB4 production in whole blood, decreased sputum L TB4 levels and was well-tolerated, and demonstrated target engagement in blood andSputum.
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Dysregulation of glucose transport and transporters in perfused hearts of genetically obese (fa/fa) rats.
TL;DR: Obese rat hearts have decreased total transporter number, and although the two stimuli studied favour the translocation of available transporters, they fail to “activate” them adequately once present in the plasma membrane.