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The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
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This article is published in The Journal of Physiology.The article was published on 1910-01-01 and is currently open access. It has received 2435 citations till now. The article focuses on the topics: Dissociation (chemistry).read more
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Toxicity Profiling of Engineered Nanomaterials via Multivariate Dose Response Surface Modeling
TL;DR: A hierarchical structure is used to account for the multivariate nature of the data by modeling dependence between outcomes and thereby combining information across cytotoxicity pathways, and a flexible surface-response model is provided that provides inference and generalizations of various classical risk assessment parameters.
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Local retention of antibodies in vivo with an injectable film embedded with a fluorogen-activating protein.
Wen Liu,Matthew J. Saunders,Christina Bagia,Eric C. Freeman,Yong Fan,Ellen S. Gawalt,Alan S. Waggoner,Wilson S. Meng +7 more
TL;DR: An injectable film by which antibodies can be localized in vivo and the ability to track IgG binding sites and distribution simultaneously will aid the optimization of local antibody delivery systems.
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Multi-scale modeling of drug binding kinetics to predict drug efficacy.
TL;DR: Current approaches of modeling drug binding kinetics that aim at improving model-based drug development in the future are discussed, which might aid in reducing the large number of failed clinical trials.
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A theoretical approach to the analysis of axonal transport.
S.I. Rubinow,J.J. Blum +1 more
TL;DR: A theoretical model of intra-axonal transport is proposed that presupposes a carrier system moving down the axon in a distal direction and predicts a spectrum of transport velocities for different proteins, in agreement with observations.
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Reproducibility of post-amphetamine [11C]FLB 457 binding to cortical D2/3 receptors.
TL;DR: Reconcibility and reliability of [11C]FLB 457 binding potential relative to non-displaceable uptake (BPND) following an acute amphetamine challenge are reported on to demonstrate that the post-amphetamine [ 11C] FLB 457 BPND is reproducible.