Open AccessJournal Article
The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
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This article is published in The Journal of Physiology.The article was published on 1910-01-01 and is currently open access. It has received 2435 citations till now. The article focuses on the topics: Dissociation (chemistry).read more
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A mathematical multiscale model of bone remodeling, accounting for pore space-specific mechanosensation
Maria Ioana Pastrama,Maria Ioana Pastrama,Stefan Scheiner,Peter Pivonka,Peter Pivonka,Christian Hellmich +5 more
TL;DR: In this article, a mathematical description of the pore spaces where the biological and biochemical events take place is proposed, accounting for biochemical regulatory mechanisms such as the RANK-RANKL-OPG pathway, coupled with a poromicromechanical model.
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The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events
Ted W. Simon,S. Stoney Simons,R. Julian Preston,Alan R. Boobis,Samuel M. Cohen,Nancy G. Doerrer,Penelope A. Fenner-Crisp,Tami S. McMullin,Charlene A. McQueen,J. Craig Rowlands,Risk Dose-Response Subteam +10 more
TL;DR: The resulting Quantitative Key Events/Dose-Response Framework (Q-KEDRF) provides a structured quantitative approach for systematic examination of the dose-response and timing of KEs resulting from a dose of a bioactive agent that causes a potential adverse outcome.
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Idiopathic Heinz Body Anaemia: Hb‐Bristol (β67 (E11) Val→Asp)
TL;DR: It is shown that the haemolytic anaemia in the original patient with ‘idiopathic Heinz body anaemia’ is due to the presence of 36% unstable haemoglobin: Hb‐Bristol (β67 (E11) Val→Asp).
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Detecting Lyme disease using antibody-functionalized single-walled carbon nanotube transistors.
TL;DR: The speed and sensitivity of this biosensor make it an ideal candidate for development as a medical diagnostic test, and the response varied strongly over a concentration range coinciding with levels of clinical interest.
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What is pharmacological 'affinity'? Relevance to biased agonism and antagonism.
TL;DR: It is shown that both the bias and relative efficacy of a ligand are essential data for fully predicting biased effects in vivo and the allosteric control of ligand affinity through receptor-signaling protein interaction is discussed within the context of biased antagonism.