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The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
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This article is published in The Journal of Physiology.The article was published on 1910-01-01 and is currently open access. It has received 2435 citations till now. The article focuses on the topics: Dissociation (chemistry).read more
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A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks
TL;DR: It is found that both forms of homeostasis provide a robust mechanism for maintaining stable activity following perturbations, and a mechanism for dynamically maintaining neural heterogeneity, and expose computational advantages of non-local homeostatic processes.
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k‐Binding and Degradation of [3H]Dynorphin A (1–8) and [3H]Dynorphin A (1–9) in Suspensions of Guinea Pig Brain Membranes
TL;DR: Comparison of the effects of peptidase inhibitors on unbound dynorphin A fragments with their effects in binding assays suggests that the bound peptides are protected from the action of peptIDases.
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Mathematical Simulation of Membrane Processes and Metabolic Fluxes of the Pancreatic β-cell
TL;DR: A new type of equation to describe enzyme-catalyzed reactions was developed, which allows the description of processes both at or near equilibrium and far from equilibrium, as they are both known to occur in the living cell.
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Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro
Matteo Goldoni,Maria Vittoria Vettori,Rossella Alinovi,Andrea Caglieri,Sandra Ceccatelli,Antonio Mutti +5 more
TL;DR: A model to fit dose‐response curves in vitro to fit in vivo toxicity data for Mn, styrene oxide and methyl‐mercury is proposed and a reasonable agreement between in vitro and in vivo data has been found.
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Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition
Sarah C. Atkinson,Sarah C. Atkinson,Con Dogovski,Matthew T. Downton,Peter E. Czabotar,Renwick C. J. Dobson,Renwick C. J. Dobson,Juliet A. Gerrard,Juliet A. Gerrard,John Wagner,Matthew A. Perugini,Matthew A. Perugini +11 more
TL;DR: This study reveals for the first time the structural mechanism for allosteric inhibition of DHDPS from the common grapevine, and demonstrates that lysine binding is both tight (relative to bacterial D HDPS orthologs) and cooperative.