Journal ArticleDOI
The potential use of receptor-mediated endocytosis for oral drug delivery.
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This article is published in Advanced Drug Delivery Reviews.The article was published on 1996-07-12. It has received 107 citations till now. The article focuses on the topics: Receptor-mediated endocytosis & Endocytosis.read more
Citations
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Nanoparticles - A Review
V J Mohanraj,Y Chen +1 more
TL;DR: Various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes are reviewed.
Journal ArticleDOI
Polymer-drug conjugation, recent achievements and general strategies
Gianfranco Pasut,Fm Veronese +1 more
TL;DR: The review will discuss the most recent achievements in polymer conjugation with special emphasis on PEG application strategies and approved products.
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Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?
TL;DR: A review of recent progress in the field of nanoparticle uptake from this site of administration examines recent progress with nanoparticles consisting of a novel class of charged comb polyesters, poly(2-sulfobutyl-vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid), SB-PVAL-g-PLGA, allowing adjustment of physicochemical nanoparticle properties with a single class of polymers.
Journal ArticleDOI
Approaches for Enhancing Oral Bioavailability of Peptides and Proteins
TL;DR: The physiological barriers to oral delivery of peptides and proteins and novel pharmaceutical approaches to circumvent these barriers and enhance oral bioavailability of these macromolecules are summarized.
Journal ArticleDOI
Oral delivery of peptide drugs: barriers and developments.
TL;DR: This review focuses on the intestinal barriers that compromise the systemic absorption of intact peptide and protein molecules and on the advanced technologies that have been developed to overcome the barriers to peptide drug absorption.
References
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Journal ArticleDOI
Endocytosis and the recycling of plasma membrane.
TL;DR: This article centers on the properties and dynamics of the endocytic vacuole membrane and stresses observations on cultured mouse macrophages with which the authors are most familier.
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Cell Surface Polarity in Epithelia
Kai Simons,S D Fuller +1 more
TL;DR: Systemes experimentaux pour etudier la biogenese de la surface cellulaire, organisation moleculaire de the surface de the cellule epitheliale, d'endocytose et transcytose, et insertion des proteines membranaires.
Journal ArticleDOI
Common themes in microbial pathogenicity.
B. Brett Finlay,Stanley Falkow +1 more
TL;DR: The degree of success of a pathogen is dependent upon the status of the host, and biochemical sensors exquisitely designed to measure and respond to such environmental stimuli and accordingly to regulate a cascade of virulence determinants essential for life within the host.
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Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis
TL;DR: The tubular vesicles are, it is proposed, an intermediate in recycling the receptor to the cell surface in rats infused with asialoglycoprotein for 60 min, and appear to transform into secondary lysosomes, wherein the ligand is degraded.
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Transepithelial transport of immunoglobulins.
TL;DR: The receptor for intestinal transport of IgG is structurally similar to class I MHC molecules, and may be regulated by the heterotrimeric Gs protein, protein kinase C and calmodulin.