The prognosis analysis of different metastasis pattern in patients with different breast cancer subtypes: a SEER based study.
TLDR
It was proven that only bone metastasis was not a prognostic factor in the HR+/HER2-, HR+ /HER2+ and HR-/her2+ subgroup, and patients with brain metastasis had the worst cancer specific survival (CSS) in all the subgroups of BCS.Abstract:
Studies on prognosis of different metastasis patterns in patients with different breast cancer subtypes (BCS) are limited. Therefore, we identified 7862 breast cancer patients with distant metastasis from 2010 to 2013 using Surveillance, Epidemiology, wand End Results (SEER) population-based data. The results showed that bone was the most common metastatic site and brain was the least common metastatic site, and the patients with HR+/HER2- occupied the highest metastasis proportion, the lowest metastasis proportion were found in HR-/HER2+ patients. Univariate and multivariate logistic regression analysis were used to analyze the association, and it was found that there were significant differences of distant metastasis patterns in patients with different BCS(different P value). Importantly, univariate and multivariate Cox regression analysis were used to analyze the prognosis. It was proven that only bone metastasis was not a prognostic factor in the HR+/HER2-, HR+/HER2+ and HR-/HER2+ subgroup (all, P > 0.05), and patients with brain metastasis had the worst cancer specific survival (CSS) in all the subgroups of BCS (all, P 0.05).read more
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Targeted therapeutic options and future perspectives for HER2-positive breast cancer.
Jiani Wang,Binghe Xu +1 more
TL;DR: This review summarizes the most significant and updated research on clinical scenarios related to HER2-positive breast cancer management in order to revise the guidelines of everyday clinical practices.
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Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with firsthand examples.
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TL;DR: Examples suggest that utilization of the interplay of pharmacology, (patho-)physiology and nanotechnology is a facile approach to develop innovative drug delivery systems and therapies with high efficiency and translational potential.
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Decaying relevance of clinical data towards future decisions in data-driven inpatient clinical order sets
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Molecular subtype predicts incidence and prognosis of brain metastasis from breast cancer in SEER database
TL;DR: The patients with HER2 and TNBC cancer subtypes having visceral metastasis, close surveillance could contribute to early detection of brain metastasis and may putatively lead to improved quality of life and survival.
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