The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: Comparative effectiveness of a time-varying treatment with competing risks
John B. Holcomb,Deborah J. del Junco,Erin E. Fox,Charles E. Wade,Mitchell J. Cohen,Martin A. Schreiber,Louis H. Alarcon,Yu Bai,Karen J. Brasel,Eileen M. Bulger,Bryan A. Cotton,Nena Matijevic,Peter Muskat,John G. Myers,Herb A. Phelan,Christopher E. White,Jiajie Zhang,Mohammad H. Rahbar +17 more
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TLDR
Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission, and among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or Platelet ratios.Abstract:
Objective To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios. Design Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models. Setting Ten US level I trauma centers. Patients Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group). Main Outcome Measure In-hospital mortality. Results Plasma:RBC and platelet:RBC ratios were not constant during the first 24 hours (P Conclusions Higher plasma and platelet ratios early in resuscitation were associated with decreased mortality in patients who received transfusions of at least 3 units of blood products during the first 24 hours after admission. Among survivors at 24 hours, the subsequent risk of death by day 30 was not associated with plasma or platelet ratios.read more
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Point-of-injury Use of Reconstituted Freeze Dried Plasma as a Resuscitative Fluid: A Special Report for Prehospital Trauma Care
Elon Glassberg,Roy Nadler,Todd E. Rasmussen,Amir Abramovich,Tomer Erlich,Lorne H. Blackbourne,Yitshak Kreiss +6 more
TL;DR: The broader implications of prehospital fluid resuscitation in the context of what is the first reported case of point-of-injury use of reconstituted, lyophilized single-donor freeze dried plasma (FDP) as a resuscitative fluid are described.
Journal ArticleDOI
Compliance with evidence-based clinical management guidelines in bleeding trauma patients.
Anne Godier,M. Bacus,Eric Kipnis,Benoît Tavernier,A. Guidat,Antoine Rauch,Elodie Drumez,Sophie Susen,D. Garrigue-Huet +8 more
TL;DR: It is found that compliance with protocols based on European guidelines impacts trauma outcome, because patient compliance was associated with survival.
Journal ArticleDOI
Does resuscitation with plasma increase the risk of venous thromboembolism
Ashley L. Zander,Erik J. Olson,Jan-Michael Van Gent,Jesse Bandle,Richard Y. Calvo,Steven R. Shackford,Kimberly A. Peck,C. Beth Sise,Michael J. Sise,Bryan S. King +9 more
TL;DR: Each unit of FFP increased VTE risk by 25% in patients who required less than 4 U of PRBCs, suggesting that FFP should be used cautiously when early hemodynamic stability can be achieved with less than4 U ofPRBCs.
Journal ArticleDOI
Modified traumatic bleeding severity score: early determination of the need for massive transfusion ☆ ☆☆ ★
TL;DR: The predictive value of the Modified TBSS of the need for MT is still high and is equivalent to the TASH score, and the ModifiedTBSS is calculated earlier in resuscitation than the original T BSS.
Journal ArticleDOI
Multicenter study of crystalloid boluses and transfusion in pediatric trauma-When to go to blood?
Stephanie F. Polites,Rachel M. Nygaard,Pooja N. Reddy,Martin D. Zielinski,Chad J. Richardson,Terri A. Elsbernd,Branden M Petrun,Sean L Weinberg,Sherrie Murphy,Donald D. Potter,Denise B. Klinkner,Christopher R. Moir +11 more
TL;DR: Almost half of pediatric trauma patients with elevated shock index require transfusion following two crystalloid boluses and the odds of requiring a transfusion plateau at this point in resuscitation support consideration of blood with the second bolus in conjunction with shock index.
References
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The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies
Erik von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
Journal ArticleDOI
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
Erik von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
Journal ArticleDOI
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
E von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The STROBE Statement is a checklist of items that should be addressed in articles reporting on the 3 main study designs of analytical epidemiology: cohort, casecontrol, and cross-sectional studies; these recommendations are not prescriptions for designing or conducting studies.
Book
Applied Survival Analysis: Regression Modeling of Time-to-Event Data
TL;DR: Applied Survival Analysis, Second Edition is an ideal book for graduate-level courses in biostatistics, statistics, and epidemiologic methods and serves as a valuable reference for practitioners and researchers in any health-related field or for professionals in insurance and government.
Journal ArticleDOI
Purposeful selection of variables in logistic regression
TL;DR: An algorithm which automates the purposeful selection of covariates within which an analyst makes a variable selection decision at each step of the modeling process and has the capability of retaining important confounding variables, resulting potentially in a slightly richer model.
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