The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Paolo Fusar-Poli,Stefan Borgwardt,Andreas Bechdolf,Jean Addington,Anita Riecher-Rössler,Frauke Schultze-Lutter,Matcheri S. Keshavan,Stephen J. Wood,Stephan Ruhrmann,Larry J. Seidman,Lucia Valmaggia,Tyrone D. Cannon,Eva Velthorst,Lieuwe de Haan,Barbara A. Cornblatt,Ilaria Bonoldi,Max Birchwood,Thomas H. McGlashan,William T. Carpenter,Patrick D. McGorry,Joachim Klosterkötter,Philip McGuire,Alison R. Yung +22 more
TLDR
The relatively new field of HR research in psychosis has the potential to shed light on the development of major psychotic disorders and to alter their course and provides a rationale for service provision to those in need of help who could not previously access it.Abstract:
Context During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. Objective To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Data Sources Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Study Selection and Data Extraction Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Data Synthesis Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. Conclusions The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.read more
Citations
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Journal ArticleDOI
Federated multi-site longitudinal study of at-risk mental state for psychosis in Japan.
Kazunori Matsumoto,Masahiro Katsura,Naohisa Tsujino,Shimako Nishiyama,Takahiro Nemoto,Naoyuki Katagiri,Tsutomu Takahashi,Yuko Higuchi,Noriyuki Ohmuro,Hiroo Matsuoka,Michio Suzuki,Masafumi Mizuno +11 more
TL;DR: The findings support the assertion that the current concept of ARMS is applicable in Japan and development of local clinical guidelines and training for clinicians is necessary to disseminate this concept to more clinical settings.
Journal ArticleDOI
Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.
Paulina Lukow,Amanda Kiemes,Matthew J. Kempton,Federico Turkheimer,Philip McGuire,Gemma Modinos +5 more
TL;DR: In this paper, the role of emotion processing abnormalities in the emergence of psychosis and the underlying neurobiology remain unclear, however, the authors systematically reviewed functional magnetic resonance studies that used emotion processing task paradigms in FEP patients, and in people at clinical high risk for psychosis (CHRp).
Journal ArticleDOI
Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell)
Felicity Waite,Thomas Kabir,Louise Johns,Jill Mollison,Apostolos Tsiachristas,Ariane Petit,Emma Černis,Emma Černis,Daniel Maughan,Daniel Freeman,Daniel Freeman +10 more
TL;DR: Treating sleep problems may prevent the onset of psychosis and reduce depression, psychotic experiences, and prevent transition to psychosis in young people at ultra-high-risk of psychosis.
Journal ArticleDOI
Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study.
Jun Konishi,Jun Konishi,Jun Konishi,Elisabetta C. del Re,Elisabetta C. del Re,Sylvain Bouix,Gabriëlla A.M. Blokland,Raquelle I. Mesholam-Gately,Kristen A. Woodberry,Margaret A. Niznikiewicz,Jill M. Goldstein,Jill M. Goldstein,Yoshio Hirayasu,Tracey L. Petryshen,Larry J. Seidman,Larry J. Seidman,Martha E. Shenton,Martha E. Shenton,Robert W. McCarley +18 more
TL;DR: Results indicate that the ratio of temporal horns volume to brain volume is abnormal in CHR compared to controls, and these abnormalities present in CHR individuals may constitute the biological basis for at least some of the CHR syndrome.
Journal ArticleDOI
Genetic risk assessment in psychiatry
TL;DR: Research on the genetic and environmental factors that increase risk for schizophrenia and etiologically related disorders are reviewed, guidance in determining and communicating risks to families is delivered, and new opportunities and challenges that will come with translating new research findings to psychiatric risk assessment and genetic counseling are anticipated.
References
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BookDOI
Reducing risks for mental disorders: Frontiers for preventive intervention research.
TL;DR: This study provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction and presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Journal ArticleDOI
A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
TL;DR: There is evidence, however, that transitory developmental expression of psychosis (psychosis proneness) may become abnormally persistent and subsequently clinically relevant (impairment), depending on the degree of environmental risk the person is additionally exposed to.
Journal ArticleDOI
Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
Alison R. Yung,Hok Pan Yuen,Patrick D. McGorry,Lisa J. Phillips,D. Kelly,Margaret Dell'Olio,Shona M. Francey,Elizabeth Cosgrave,Eoin Killackey,Carrie Stanford,Katherine Godfrey,Joe A. Buckby +11 more
TL;DR: The CAARMS instrument provides a useful platform for monitoring sub threshold psychotic symptoms for worsening into full-threshold psychotic disorder and has good to excellent reliability.
Journal ArticleDOI
Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability
Tandy J. Miller,Thomas H. McGlashan,Joanna Lifshey Rosen,Kristen Cadenhead,Joseph Ventura,William R. McFarlane,Diana O. Perkins,Godfrey D. Pearlson,Scott W. Woods +8 more
TL;DR: Data is presented suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop and on the Structured Interview for Prodromal Syndromes and the Scale of ProDromal Symptoms.
Journal ArticleDOI
Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.
Christos Pantelis,Christos Pantelis,Dennis Velakoulis,Dennis Velakoulis,Patrick D. McGorry,Stephen J. Wood,Stephen J. Wood,John Suckling,Lisa J. Phillips,Alison R. Yung,Edward T. Bullmore,Warrick J. Brewer,Warrick J. Brewer,Bridget Soulsby,Bridget Soulsby,Patricia Desmond,Philip McGuire +16 more
TL;DR: Some of the grey-matter abnormalities associated with psychotic disorders predate the onset of frank symptoms, whereas others appear in association with their first expression.