The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Paolo Fusar-Poli,Stefan Borgwardt,Andreas Bechdolf,Jean Addington,Anita Riecher-Rössler,Frauke Schultze-Lutter,Matcheri S. Keshavan,Stephen J. Wood,Stephan Ruhrmann,Larry J. Seidman,Lucia Valmaggia,Tyrone D. Cannon,Eva Velthorst,Lieuwe de Haan,Barbara A. Cornblatt,Ilaria Bonoldi,Max Birchwood,Thomas H. McGlashan,William T. Carpenter,Patrick D. McGorry,Joachim Klosterkötter,Philip McGuire,Alison R. Yung +22 more
TLDR
The relatively new field of HR research in psychosis has the potential to shed light on the development of major psychotic disorders and to alter their course and provides a rationale for service provision to those in need of help who could not previously access it.Abstract:
Context During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. Objective To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Data Sources Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Study Selection and Data Extraction Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Data Synthesis Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. Conclusions The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.read more
Citations
More filters
Journal ArticleDOI
Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative.
Anna R. Docherty,Anna R. Docherty,Eduardo Fonseca-Pedrero,Martin Debbané,Martin Debbané,Raymond C.K. Chan,Richard J. Linscott,Katherine G. Jonas,David C. Cicero,Melissa J. Green,Leonard J. Simms,Oliver Mason,David Watson,Ulrich Ettinger,Monika A. Waszczuk,Alexander Rapp,Phillip Grant,Phillip Grant,Roman Kotov,Colin G. DeYoung,Camilo J. Ruggero,Nicolas R Eaton,Robert F. Krueger,Christopher J. Patrick,Christopher J. Hopwood,F. Anthony O'Neill,David H. Zald,Christopher C. Conway,Daniel E. Adkins,Irwin D. Waldman,Jim van Os,Jim van Os,Jim van Os,Patrick F. Sullivan,Patrick F. Sullivan,John S. Anderson,Andrey A. Shabalin,Scott R. Sponheim,Stephan F. Taylor,Rachel G Grazioplene,Silviu Alin Bacanu,Tim B. Bigdeli,Tim B. Bigdeli,Corinna Haenschel,Dolores Malaspina,Diane C. Gooding,Kristin K. Nicodemus,Frauke Schultze-Lutter,Neus Barrantes-Vidal,Neus Barrantes-Vidal,Christine Mohr,William T. Carpenter,Alex S. Cohen +52 more
TL;DR: It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum.
Journal ArticleDOI
Prevalence of Individuals at Clinical High-risk of Psychosis in the General Population and Clinical Samples: Systematic Review and Meta-analysis
TL;DR: In this article, the authors evaluated the prevalence of CHR-P individuals systematically assessed in the general population or clinical samples in 35 studies, with 37,135 individuals tested and 1554 individuals identified (median age = 19.3 years, Interquartile range (IQR) = 15.8-22.1; 52.2% females, IQR = 38.7-64.4).
Journal ArticleDOI
The prodromal phase of psychosis
Gemma Modinos,Philip McGuire +1 more
TL;DR: A key challenge for research in this field is to translate findings in new findings that have significantly advanced understanding of the neurobiology of psychosis into improvements in the clinical management of the early phase of psychosis.
Journal ArticleDOI
Clinical Effects of Mindfulness-Based Intervention in Patients With First Episode Psychosis and in Individuals With Ultra-High Risk for Transition to Psychosis: A Review
TL;DR: Future sham-controlled studies with large sample sizes are needed to definitively conclude on the clinical interest of mindfulness-based interventions in FEP patients and UHR individuals as well as to understand their underlying mechanisms of action.
Journal ArticleDOI
Cingulum bundle abnormalities and risk for schizophrenia.
Jennifer Fitzsimmons,Pedro Rosa,Valerie J. Sydnor,Benjamin Reid,Nikos Makris,Jill M. Goldstein,Raquelle I. Mesholam-Gately,Kristen A. Woodberry,Joanne Wojcik,Robert W. McCarley,Larry J. Seidman,Martha E. Shenton,Marek Kubicki +12 more
TL;DR: Findings suggest abnormalities (possibly myelin related) in the CB in individuals at clinical high risk for psychosis are suggested.
References
More filters
BookDOI
Reducing risks for mental disorders: Frontiers for preventive intervention research.
TL;DR: This study provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction and presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Journal ArticleDOI
A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
TL;DR: There is evidence, however, that transitory developmental expression of psychosis (psychosis proneness) may become abnormally persistent and subsequently clinically relevant (impairment), depending on the degree of environmental risk the person is additionally exposed to.
Journal ArticleDOI
Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
Alison R. Yung,Hok Pan Yuen,Patrick D. McGorry,Lisa J. Phillips,D. Kelly,Margaret Dell'Olio,Shona M. Francey,Elizabeth Cosgrave,Eoin Killackey,Carrie Stanford,Katherine Godfrey,Joe A. Buckby +11 more
TL;DR: The CAARMS instrument provides a useful platform for monitoring sub threshold psychotic symptoms for worsening into full-threshold psychotic disorder and has good to excellent reliability.
Journal ArticleDOI
Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability
Tandy J. Miller,Thomas H. McGlashan,Joanna Lifshey Rosen,Kristen Cadenhead,Joseph Ventura,William R. McFarlane,Diana O. Perkins,Godfrey D. Pearlson,Scott W. Woods +8 more
TL;DR: Data is presented suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop and on the Structured Interview for Prodromal Syndromes and the Scale of ProDromal Symptoms.
Journal ArticleDOI
Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.
Christos Pantelis,Christos Pantelis,Dennis Velakoulis,Dennis Velakoulis,Patrick D. McGorry,Stephen J. Wood,Stephen J. Wood,John Suckling,Lisa J. Phillips,Alison R. Yung,Edward T. Bullmore,Warrick J. Brewer,Warrick J. Brewer,Bridget Soulsby,Bridget Soulsby,Patricia Desmond,Philip McGuire +16 more
TL;DR: Some of the grey-matter abnormalities associated with psychotic disorders predate the onset of frank symptoms, whereas others appear in association with their first expression.