The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Paolo Fusar-Poli,Stefan Borgwardt,Andreas Bechdolf,Jean Addington,Anita Riecher-Rössler,Frauke Schultze-Lutter,Matcheri S. Keshavan,Stephen J. Wood,Stephan Ruhrmann,Larry J. Seidman,Lucia Valmaggia,Tyrone D. Cannon,Eva Velthorst,Lieuwe de Haan,Barbara A. Cornblatt,Ilaria Bonoldi,Max Birchwood,Thomas H. McGlashan,William T. Carpenter,Patrick D. McGorry,Joachim Klosterkötter,Philip McGuire,Alison R. Yung +22 more
TLDR
The relatively new field of HR research in psychosis has the potential to shed light on the development of major psychotic disorders and to alter their course and provides a rationale for service provision to those in need of help who could not previously access it.Abstract:
Context During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. Objective To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Data Sources Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Study Selection and Data Extraction Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Data Synthesis Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. Conclusions The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.read more
Citations
More filters
Journal ArticleDOI
European status and perspectives on early detection and intervention in at-risk mental state and first episode psychosis: Viewpoint from the EPA section for prevention of mental disorders.
N. Maric,Andrea Raballo,M. Rojnic Kuzman,S. Andric Petrovic,Joachim Klosterkötter,Anita Riecher-Rössler +5 more
Journal ArticleDOI
Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.
Line K. Johnsen,Line K. Johnsen,Anna Hester Ver Loren van Themaat,Anna Hester Ver Loren van Themaat,Kit Melissa Larsen,Birgitte Klee Burton,W. Baare,Kathrine Skak Madsen,Merete Nordentoft,Merete Nordentoft,Merete Nordentoft,Hartwig R. Siebner,Hartwig R. Siebner,Kerstin Jessica Plessen,Kerstin Jessica Plessen,Kerstin Jessica Plessen +15 more
TL;DR: These studies provide evidence for altered brain processing of emotions in children, adolescents, and young adults at FHR-BD and pinpoint specific alterations in brain activation during cognitive-, emotional-, and reward-related tasks.
Journal ArticleDOI
Global and Specific Profiles of Executive Functioning in Prodromal and Early Psychosis.
Wu Jeong Hwang,Tae Young Lee,Won Gyo Shin,Minah Kim,Minah Kim,Jihyang Kim,Junhee Lee,Junhee Lee,Jun Soo Kwon +8 more
TL;DR: The findings of this study highlight the informative value of the specific subdomains of semantic fluency and spatial working memory in executive functioning in prodromal and early psychosis patients.
Journal ArticleDOI
Molecular Genetic Risk for Psychosis Is Associated With Psychosis Risk Symptoms in a Population-Based UK Cohort: Findings From Generation Scotland.
Anna R. Docherty,Anna R. Docherty,Andrey A. Shabalin,Daniel E. Adkins,Frank D. Mann,Robert F. Krueger,Silviu Alin Bacanu,Archie Campbell,Caroline Hayward,David J. Porteous,Andrew M. McIntosh,Kenneth S. Kendler +11 more
TL;DR: Empirically derived symptom factor scores reflected interpersonal/negative symptoms and were positively associated with polygenic risk for schizophrenia, largely sex specific and limited to males, and across both sexes, scores were positive associated with neuroticism and major depressive disorder.
Journal ArticleDOI
Prolonged cortical silent period among drug-naive subjects at ultra-high risk of psychosis.
Yingying Tang,Tianhong Zhang,Bradley J. Edelman,Botao Zeng,Shanshan Zhao,Chunyan Li,Kaiming Zhuo,Zhenying Qian,Hui Li,Qian Guo,HuiRu Cui,Yikang Zhu,Lijuan Jiang,Chunbo Li,Dehua Yu,Jijun Wang +15 more
TL;DR: Cortical inhibitory deficits among UHR subjects were relatively limited compared to those among schizophrenia patients, while alterations in both GABAA and GABAB networks might contribute to full-blown psychosis.
References
More filters
BookDOI
Reducing risks for mental disorders: Frontiers for preventive intervention research.
TL;DR: This study provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction and presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Journal ArticleDOI
A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
TL;DR: There is evidence, however, that transitory developmental expression of psychosis (psychosis proneness) may become abnormally persistent and subsequently clinically relevant (impairment), depending on the degree of environmental risk the person is additionally exposed to.
Journal ArticleDOI
Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
Alison R. Yung,Hok Pan Yuen,Patrick D. McGorry,Lisa J. Phillips,D. Kelly,Margaret Dell'Olio,Shona M. Francey,Elizabeth Cosgrave,Eoin Killackey,Carrie Stanford,Katherine Godfrey,Joe A. Buckby +11 more
TL;DR: The CAARMS instrument provides a useful platform for monitoring sub threshold psychotic symptoms for worsening into full-threshold psychotic disorder and has good to excellent reliability.
Journal ArticleDOI
Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability
Tandy J. Miller,Thomas H. McGlashan,Joanna Lifshey Rosen,Kristen Cadenhead,Joseph Ventura,William R. McFarlane,Diana O. Perkins,Godfrey D. Pearlson,Scott W. Woods +8 more
TL;DR: Data is presented suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop and on the Structured Interview for Prodromal Syndromes and the Scale of ProDromal Symptoms.
Journal ArticleDOI
Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.
Christos Pantelis,Christos Pantelis,Dennis Velakoulis,Dennis Velakoulis,Patrick D. McGorry,Stephen J. Wood,Stephen J. Wood,John Suckling,Lisa J. Phillips,Alison R. Yung,Edward T. Bullmore,Warrick J. Brewer,Warrick J. Brewer,Bridget Soulsby,Bridget Soulsby,Patricia Desmond,Philip McGuire +16 more
TL;DR: Some of the grey-matter abnormalities associated with psychotic disorders predate the onset of frank symptoms, whereas others appear in association with their first expression.