The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Paolo Fusar-Poli,Stefan Borgwardt,Andreas Bechdolf,Jean Addington,Anita Riecher-Rössler,Frauke Schultze-Lutter,Matcheri S. Keshavan,Stephen J. Wood,Stephan Ruhrmann,Larry J. Seidman,Lucia Valmaggia,Tyrone D. Cannon,Eva Velthorst,Lieuwe de Haan,Barbara A. Cornblatt,Ilaria Bonoldi,Max Birchwood,Thomas H. McGlashan,William T. Carpenter,Patrick D. McGorry,Joachim Klosterkötter,Philip McGuire,Alison R. Yung +22 more
TLDR
The relatively new field of HR research in psychosis has the potential to shed light on the development of major psychotic disorders and to alter their course and provides a rationale for service provision to those in need of help who could not previously access it.Abstract:
Context During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. Objective To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Data Sources Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Study Selection and Data Extraction Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Data Synthesis Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. Conclusions The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.read more
Citations
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Journal ArticleDOI
Où en sommes-nous? An Overview of Successes and Challenges after 30 Years of Early Intervention Services for Psychosis in Quebec: Où en sommes-nous? Un aperçu des réussites et des problèmes après 30 ans de services d'intervention précoce pour la psychose au Québec.
Bastian Bertulies-Esposito,Marie Nolin,Srividya N. Iyer,Srividya N. Iyer,Ashok Malla,Ashok Malla,Phil Tibbo,Nicola Otter,Manuela Ferrari,Manuela Ferrari,Amal Abdel-Baki +10 more
TL;DR: In this article, early intervention services (EIS) for first-episode psychosis (FEP) were gradually implemented in the province of Quebec over the last 30 years, without p...
Journal ArticleDOI
The Mediating Role of Stress in the Relationship Between Attention to Threat Bias and Psychotic-Like Experiences Depends on Coping Strategies.
TL;DR: Perceived stress was found to serve as a partial mediator in the relationship linking attention to threat (ATB) and external attribution biases (ETB) with psychotic-like experiences and both perceived stress and coping styles are important factors affecting the association between cognitive biases and psychotic- like experiences.
Journal ArticleDOI
Relationships between intra-individual variability and subclinical psychosis
TL;DR: In this paper, Schizotypy and psychotic-like experiences (PLE) were assessed via interview and questionnaire, and participants completed both a simple reaction time (SRT) task and a continuous performance task-identical pairs version (CPT-IP).
Journal ArticleDOI
Identifying psychosis spectrum youth using support vector machines and cerebral blood perfusion as measured by arterial spin labeled fMRI.
Dawson J. Overton,Nikhil Bhagwat,Joseph D. Viviano,Grace Jacobs,Aristotle N. Voineskos,Aristotle N. Voineskos +5 more
TL;DR: Psychosis spectrum (PS) youth can be identified with support vector machines and classification is improved when youth with psychiatric comorbidities are excluded.
Journal ArticleDOI
Polygenic risk scores across the extended psychosis spectrum.
Lukasz Smigielski,Sergi Papiol,Anastasia Theodoridou,Karsten Heekeren,Miriam Gerstenberg,Diana Wotruba,Roman Buechler,Per Hoffmann,Per Hoffmann,Stefan Herms,Stefan Herms,Kristina Adorjan,Heike Anderson-Schmidt,Monika Budde,Ashley L. Comes,Ashley L. Comes,Katrin Gade,Maria Heilbronner,Urs Heilbronner,Janos Kalman,Janos Kalman,Farahnaz Klöhn-Saghatolislam,Daniela Reich-Erkelenz,Sabrina K. Schaupp,Eva C. Schulte,Fanny Senner,Ion-George Anghelescu,Volker Arolt,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Udo Dannlowski,Detlef E. Dietrich,Andreas J. Fallgatter,Christian Figge,Markus Jäger,Georg Juckel,Carsten Konrad,Vanessa Nieratschker,Jens Reimer,Eva Z. Reininghaus,Max Schmauß,Carsten Spitzer,Martin von Hagen,Jens Wiltfang,Jens Wiltfang,Jens Wiltfang,Jörg Zimmermann,Anna Gryaznova,Laura Flatau-Nagel,Markus Reitt,Milena Meyers,Barbara Emons,Ida Sybille Haußleiter,Fabian U. Lang,Thomas Becker,Moritz E. Wigand,Stephanie H. Witt,Franziska Degenhardt,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Marcella Rietschel,Markus M. Nöthen,Till F. M. Andlauer,Wulf Rössler,Wulf Rössler,Wulf Rössler,Susanne Walitza,Peter Falkai,Thomas G. Schulze,Thomas G. Schulze,Thomas G. Schulze,Edna Grünblatt +73 more
TL;DR: In this article, polygenic risk scores for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies.
References
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BookDOI
Reducing risks for mental disorders: Frontiers for preventive intervention research.
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Journal ArticleDOI
Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States
Alison R. Yung,Hok Pan Yuen,Patrick D. McGorry,Lisa J. Phillips,D. Kelly,Margaret Dell'Olio,Shona M. Francey,Elizabeth Cosgrave,Eoin Killackey,Carrie Stanford,Katherine Godfrey,Joe A. Buckby +11 more
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Journal ArticleDOI
Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability
Tandy J. Miller,Thomas H. McGlashan,Joanna Lifshey Rosen,Kristen Cadenhead,Joseph Ventura,William R. McFarlane,Diana O. Perkins,Godfrey D. Pearlson,Scott W. Woods +8 more
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Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.
Christos Pantelis,Christos Pantelis,Dennis Velakoulis,Dennis Velakoulis,Patrick D. McGorry,Stephen J. Wood,Stephen J. Wood,John Suckling,Lisa J. Phillips,Alison R. Yung,Edward T. Bullmore,Warrick J. Brewer,Warrick J. Brewer,Bridget Soulsby,Bridget Soulsby,Patricia Desmond,Philip McGuire +16 more
TL;DR: Some of the grey-matter abnormalities associated with psychotic disorders predate the onset of frank symptoms, whereas others appear in association with their first expression.