Journal ArticleDOI
The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission.
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TLDR
The potential of the NPS system as a treatment target for addiction is analyzed, with particular attention to the interpretation of findings revealing complex neuroanatomical and functional interactions between NPS, CRF, and the Hcrt-1/Ox-A systems.About:
This article is published in Progress in Neurobiology.The article was published on 2013-01-01. It has received 37 citations till now. The article focuses on the topics: Addiction & Neuropeptide S.read more
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Journal ArticleDOI
Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress.
TL;DR: An interwoven relationship is suggested, linked by social context, between amygdalar BDNF, NPS and plasma corticosterone and submissive animals that chose submissive coexistence.
Journal ArticleDOI
Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S.
Massimo Ubaldi,Antonio Giordano,Ilenia Severi,Hongwu Li,Marsida Kallupi,Giordano de Guglielmo,Barbara Ruggeri,Serena Stopponi,Roberto Ciccocioppo,Nazzareno Cannella,Nazzareno Cannella +10 more
TL;DR: Results suggest that the Hcrt-1/Ox-A neurocircuitry mediating the facilitation of cue-induced reinstatement by NPS involves structures critically involved in stress regulation such as the PVN and the BNST.
Journal ArticleDOI
Neuropeptide S receptor gene variant and environment: contribution to alcohol use disorders and alcohol consumption
Kariina Laas,Andreas Reif,Kirsti Akkermann,Evelyn Kiive,Katharina Domschke,Klaus-Peter Lesch,Klaus-Peter Lesch,Toomas Veidebaum,Jaanus Harro +8 more
TL;DR: In the general population, the NPSR1 Asn107Ile polymorphism is associated with AUD and alcohol consumption, dependent on sex, environment and age, in line with the impulsivity and personality regulating role of the N PSR1.
Journal ArticleDOI
Intensity of anxiety is modified via complex integrative stress circuitries
Justin P. Smith,Melissa A. Prince,Justin K. Achua,James M. Robertson,Raymond T. Anderson,Patrick J. Ronan,Cliff H. Summers +6 more
TL;DR: Gene expression of NPS and brain-derived neurotrophic factor in the central amygdala (CeA), as well as corticosterone secretion, increased concomitantly with the escalating anxious content of the mouse-specific anxiety continuum, suggesting that NPS production was promoted by increasing anxiousness, and that BDNF synthesis was associated with learning about ever-more anxious conditions.
Dissertation
Neuropeptide S and mental health: A functional receptor gene variant and environment shaping traits and contributing to psychiatric disorders
Abstract: Hiljutiavastatud neuropeptiid S (NPS) avaldab narilistel omaparast moju, suurendades aktiivsust ja virgust samaaegselt arevuse alandamisega. Inimesel on NPS retseptori geenis NPSR1 funktsionaalne A>T polumorfism (rs324981), mille T-alleeli kooditud retseptorvalk on signaali vahendamisel tohusam. T-alleeli kandlus on seotud suurema virguse, kuid ka paanikahairega, mistottu on T-alleeli hakatud pidama riskialleeliks. Vaitekirjas kajastatud rahvastikupohiste uuringutega loime tasakaalustatuma pildi NPSR1 toimimisest, leides nii soost kui keskkonnast soltuvaid seoseid. Leidsime, et naistel, kellel on madalaima aktiivsusega NPSR1 genotuup, AA, voib juba teismeeas meeleolu ja arevuse regulatsiooniga raskusi olla. Mitteadaptiivsed jooned ilmnesid neil sagedamini just kehvade peresuhete korral, nagu ka suitsiidikatsed 18-ndaks ning arevus- ning meeleoluhaired 25-ndaks eluaastaks. Sagedamini kujunes A-alleeliga naistel valja ka alkoholisoltuvushaire. Seevastu meestel oli NPSR1 T-alleel, eriti TT genotuup, seotud huperaktiivsuse ja impulsiivsusega, ning stressirikkad elusundmused tostsid neid omadusi veelgi rohkem esile. Seetottu pole ullatav, et T-alleeliga meeste hulgas oli oluliselt rohkem soltuvushaireid. Huvitaval kombel raporteerisid sarnaselt naistega alkoholiga liialdamist taiskasvanuna hoopis AA genotuubiga mehed, mis viitab voimalikule taiendavale hilise algusega soltuvuse tekkimise rajale: AA meestel tousid adaptiivne impulsiivsus ja avatus oluliselt 25-ndaks eluaastaks, ning nad olid ka alkoholi kuritarvitamisele vastuvotlikumad. Kas neil ka hiljem soltuvus kujuneb, jaab tuleviku uuringute selgitada. NPSR on huvipakkuv sihtmark ravimiarenduseks, kuna mojutab virgust, emotsionaalseid reaktsioone ja alkoholi kuritarvitamist. AA ja TThomosugootide erinevaid emotsioonide reguleerimise viise on vaja sugavuti tundma oppida.; In this dissertation, we have focused on the functional rs324981 A>T polymorphism of the gene NPSR1 (Asn107Ile) that encodes for the neuropeptide S (NPS) receptor and is a relatively newly identified research target. We have shown that NPSR1 is associated with the development of personality, hyperactivity, anxiety, depressiveness, self-esteem, suicidality, affective/anxiety disorders, alcohol use and alcohol use disorders, and sleep-related measures. We have also found profound NPSR1 genotype by sex interactions in general population.
In females, the probable lower NPS-ergic activity in the NPSR1 A-allele carriers, and especially in AA-homozygotes, bears a risk for affective and anxiety-related dysregulation already in adolescence. The risk for developing maladaptive traits is significantly higher in case of adverse family environment. As a consequence, females with the AA genotype had reported suicidal behaviour more frequently and had more often developed affective/anxiety disorders by age 25. Emotion dysregulation may also render them vulnerable to alcohol use, as some females carrying the A-allele develop AUD already in young adulthood.
In males, an impulsivity-related early-onset pathway to…
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