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Barbara Ruggeri
Researcher at King's College London
Publications - 56
Citations - 2176
Barbara Ruggeri is an academic researcher from King's College London. The author has contributed to research in topics: Autism spectrum disorder & Autism. The author has an hindex of 22, co-authored 52 publications receiving 1740 citations. Previous affiliations of Barbara Ruggeri include University of Camerino & University of London.
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Journal ArticleDOI
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Gunter Schumann,Chunyu Liu,Chunyu Liu,Paul F. O'Reilly,He Gao,Parkyong Song,Bing Xu,Barbara Ruggeri,Najaf Amin,Tianye Jia,Sarah R. Preis,Marcelo P. Segura Lepe,Marcelo P. Segura Lepe,Shizuo Akira,Caterina Barbieri,Sebastian E. Baumeister,Sebastian E. Baumeister,Stéphane Cauchi,Toni-Kim Clarke,Stefan Enroth,Krista Fischer,Jenni Hällfors,Sarah E. Harris,Saskia Hieber,Edith Hofer,Jouke-Jan Hottenga,Åsa Johansson,Peter K. Joshi,Niina E. Kaartinen,Jaana Laitinen,Rozenn N. Lemaitre,Anu Loukola,Jian'an Luan,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Ani Manichaikul,Hamdi Mbarek,Yuri Milaneschi,Alireza Moayyeri,Alireza Moayyeri,Kenneth J. Mukamal,Christopher P. Nelson,Christopher P. Nelson,Jennifer A. Nettleton,Eemil Partinen,Rajesh Rawal,Antonietta Robino,Lynda M. Rose,Cinzia Sala,Takashi Satoh,Reinhold Schmidt,Katharina E. Schraut,Robert A. Scott,Albert V. Smith,John M. Starr,Alexander Teumer,Stella Trompet,André G. Uitterlinden,André G. Uitterlinden,Cristina Venturini,Anne-Claire Vergnaud,Niek Verweij,Veronique Vitart,Dragana Vuckovic,Juho Wedenoja,Loic Yengo,Bing Yu,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Dorret I. Boomsma,John C. Chambers,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Toniolo Daniela,Eco J. C. de Geus,Ian J. Deary,Johan G. Eriksson,Tõnu Esko,Volker Eulenburg,Oscar H. Franco,Philippe Froguel,Philippe Froguel,Christian Gieger,Hans J. Grabe,Vilmundur Gudnason,Ulf Gyllensten,Tamara B. Harris,Anna-Liisa Hartikainen,Andrew C. Heath,Lynne J. Hocking,Albert Hofman,Cornelia Huth,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,J. Wouter Jukema,Jaakko Kaprio,Jaakko Kaprio,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Zoltán Kutalik,Jari Lahti,Claudia Langenberg,Terho Lehtimäki,Yongmei Liu,Pamela A. F. Madden,Nicholas G. Martin,Alanna C. Morrison,Brenda W.J.H. Penninx,Nicola Pirastu,Nicola Pirastu,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Paul M. Ridker,Paul M. Ridker,Richard J. Rose,Jerome I. Rotter,Nilesh J. Samani,Nilesh J. Samani,Helena Schmidt,Tim D. Spector,David J. Stott,David P. Strachan,Ioanna Tzoulaki,Ioanna Tzoulaki,Pim van der Harst,Cornelia M. van Duijn,Pedro Marques-Vidal,Peter Vollenweider,Nicholas J. Wareham,John Whitfield,James G. Wilson,Bruce H W Wolffenbuttel,Georgy Bakalkin,Evangelos Evangelou,Evangelos Evangelou,Yun Liu,Yun Liu,Kenneth Rice,Sylvane Desrivières,Steven A. Kliewer,David J. Mangelsdorf,Christian P. Müller,Daniel Levy,Paul Elliott +149 more
TL;DR: It is shown that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain, suggesting that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.
Journal ArticleDOI
The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders
Eva Loth,Tony Charman,Luke Mason,Julian Tillmann,Emily J.H. Jones,Caroline Wooldridge,Jumana Ahmad,Bonnie Auyeung,Bonnie Auyeung,Claudia Brogna,Sara Ambrosino,Tobias Banaschewski,Simon Baron-Cohen,Sarah Baumeister,Christian F. Beckmann,Michael Brammer,Daniel Brandeis,Daniel Brandeis,Sven Bölte,Thomas Bourgeron,Carsten Bours,Yvette de Bruijn,Bhismadev Chakrabarti,Daisy Crawley,Ineke Cornelissen,Flavio Dell' Acqua,Guillaume Dumas,Sarah Durston,Christine Ecker,Christine Ecker,Jessica Faulkner,Vincent Frouin,Pilar Garcés,David Goyard,Hannah Hayward,Lindsay Ham,Joerg F. Hipp,Rosemary Holt,Mark H. Johnson,Johan Isaksson,Johan Isaksson,Prantik Kundu,Meng-Chuan Lai,Meng-Chuan Lai,Xavier Liogier d'Ardhuy,Michael V. Lombardo,Michael V. Lombardo,David J. Lythgoe,René C.W. Mandl,Andreas Meyer-Lindenberg,Carolin Moessnang,Nico Mueller,Laurence O'Dwyer,Marianne Oldehinkel,Bob Oranje,Gahan Pandina,Antonio M. Persico,Antonio M. Persico,Amber N. V. Ruigrok,Barbara Ruggeri,Jessica Sabet,Roberto Sacco,Antonia San José Cáceres,Emily Simonoff,Roberto Toro,Heike Tost,Jack Waldman,Steve C.R. Williams,Marcel P. Zwiers,Will Spooren,Declan G. Murphy,Jan K. Buitelaar +71 more
TL;DR: LEAP is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD and is expected to enable it to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities.
Journal ArticleDOI
Biomarkers in autism spectrum disorder: the old and the new
TL;DR: Biomarker research has great heuristic potential in targeting autism diagnosis and treatment and will eventually merge with novel biomarkers identified using unbiased genomic, epigenomic, transcriptomic, proteomic and metabolomic methods, to generate multimarker panels.
Journal ArticleDOI
The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
Tony Charman,Eva Loth,Julian Tillmann,Daisy Crawley,Caroline Wooldridge,David Goyard,Jumana Ahmad,Bonnie Auyeung,Bonnie Auyeung,Sara Ambrosino,Tobias Banaschewski,Simon Baron-Cohen,Sarah Baumeister,Christian F. Beckmann,Sven Bölte,Sven Bölte,Thomas Bourgeron,Carsten Bours,Michael Brammer,Daniel Brandeis,Claudia Brogna,Yvette de Bruijn,Bhismadev Chakrabarti,Bhismadev Chakrabarti,Ineke Cornelissen,Flavio Dell' Acqua,Guillaume Dumas,Sarah Durston,Christine Ecker,Christine Ecker,Jessica Faulkner,Vincent Frouin,Pilar Garcés,Lindsay Ham,Hannah Hayward,Joerg F. Hipp,Rosemary Holt,Johan Isaksson,Johan Isaksson,Mark H. Johnson,Emily J.H. Jones,Prantik Kundu,Meng-Chuan Lai,Meng-Chuan Lai,Xavier Liogier d'Ardhuy,Michael V. Lombardo,Michael V. Lombardo,David J. Lythgoe,René C.W. Mandl,Luke Mason,Andreas Meyer-Lindenberg,Carolin Moessnang,Nico Mueller,Laurence O'Dwyer,Marianne Oldehinkel,Bob Oranje,Gahan Pandina,Antonio M. Persico,Antonio M. Persico,Barbara Ruggeri,Amber N. V. Ruigrok,Jessica Sabet,Roberto Sacco,Antonia San José Cáceres,Emily Simonoff,Roberto Toro,Heike Tost,Jack Waldman,Steve C.R. Williams,Marcel P. Zwiers,Will Spooren,Declan G. Murphy,Jan K. Buitelaar +72 more
TL;DR: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort, with only minimal to moderate site differences on core clinical and cognitive measures.
Journal ArticleDOI
Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking
Serena Stopponi,Lorenzo Somaini,Andrea Cippitelli,Andrea Cippitelli,Nazzareno Cannella,Simone Braconi,Marsida Kallupi,Barbara Ruggeri,Markus Heilig,Gregory Demopulos,George Gaitanaris,Maurizio Massi,Roberto Ciccocioppo +12 more
TL;DR: Findings provide new information about the role of brain PPARγ receptors and identify pioglitazone as candidate treatments for alcoholism and possibly other addictions.