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The Rotterdam study
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This article is published in Nihon rinsho. Japanese journal of clinical medicine.The article was published on 2011-10-01 and is currently open access. It has received 2246 citations till now. The article focuses on the topics: Rotterdam Study.read more
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The complex interplay of cardiovascular system and cognition: how to predict dementia in the elderly?
TL;DR: More research is needed in this area, specifically, placebo-controlled randomized trials in both mid-life and late-life with cognitive dysfunction as a primary endpoint and control of cardiovascular risk factors linked to beneficial effects in terms of cognition.
Book ChapterDOI
Endoplasmic Reticulum Stress as a Primary Pathogenic Mechanism Leading to Age-Related Macular Degeneration
TL;DR: It is proposed that misfolded-protein-induced ER stress in the retinal-pigmented epithelium and/or choroid could lead to chronic oxidative stress, complement deregulation and AMD, and small molecules targeted to ER stress and oxidative stress could allow for a shift from disease treatment to disease prevention.
Journal ArticleDOI
CCDC102B confers risk of low vision and blindness in high myopia.
Yoshikatsu Hosoda,Munemitsu Yoshikawa,Masahiro Miyake,Yasuharu Tabara,Noriaki Shimada,Wanting Zhao,Akio Oishi,Hideo Nakanishi,Masayuki Hata,Tadamichi Akagi,Sotaro Ooto,Natsuko Nagaoka,Yuxin Fang,Kyoko Ohno-Matsui,Ching-Yu Cheng,Seang-Mei Saw,Ryo Yamada,Fumihiko Matsuda,Akitaka Tsujikawa,Kenji Yamashiro +19 more
TL;DR: Hosoda et al. find that rs11873439 intronic to CCDC102B is associated with myopic maculopathy, but not with myopia, thus representing a risk factor independent of myopia.
Journal ArticleDOI
Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke
Bettina Hjelm Clausen,Martin Wirenfeldt,Martin Wirenfeldt,Sofie Sander Høgedal,Lars Henrik Frich,Helle Hvilsted Nielsen,Helle Hvilsted Nielsen,Henrik Daa Schrøder,Kamilla Østergaard,Bente Finsen,Bjarne Winther Kristensen,Bjarne Winther Kristensen,Kate Lykke Lambertsen +12 more
TL;DR: The results suggest that TNF and IL-1 are expressed by subsets of cells and that TNFR2 is expressed in areas with increased astrocytic reactivity and the hypothesis that targeting post-stroke inflammation could be a promising add-on therapy in ischemic stroke patients is supported.
Journal ArticleDOI
Longitudinal association between serum urate and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Huifen Wang,Huifen Wang,David R. Jacobs,Angelo L. Gaffo,Myron D. Gross,David C. Goff,David C. Goff,J. Jeffrey Carr,J. Jeffrey Carr +8 more
TL;DR: The aim of the present study was to determine whether serum urate (sUA) concentration is positively associated with subclinical atherosclerosis, independent of body mass index (BMI).
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.