The structure of the vimentin gene.
TLDR
Comparison of the amino acid sequence of vimentin with prekeratin sequences shows that there is lesser homology of primary structure, but both the position and size of alpha-helical regions are strongly conserved.About:
This article is published in Cell.The article was published on 1983-11-01 and is currently open access. It has received 190 citations till now. The article focuses on the topics: Vimentin & Sequence analysis.read more
Citations
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Journal ArticleDOI
The mosaic genome of warm-blooded vertebrates.
Giorgio Bernardi,Birgitta Olofsson,Jan Filipski,Marino Zerial,Julio Salinas,Gérard Cuny,Michele Meunier-Rotival,Francis Rodier +7 more
TL;DR: This approach has revealed that the distribution of genes, integrated viral sequences, and interspersed repeats is highly nonuniform in the genome, and that the base composition and ratio of CpG to GpC in both coding and noncoding sequences, as well as codon usage, mainly depend on the GC content of the isochores harboring the sequences.
Journal ArticleDOI
Neuronal Intermediate Filaments
TL;DR: Because aberrant accumulation of NFs is a common pathology in a series of motor neuron diseases-including amyotrophic lateral sclerosis-NF misaccumulation, and the resultant disruption in axonal transport, is probably a key intermediate in the pathogenesis of these diseases, this work concludes that NF investment into axons is essential for establishment of axonal caliber.
Journal ArticleDOI
The molecular biology of intermediate filaments.
TL;DR: The field of IF has now matured to the point where it is being explored by the various approaches generically termed “molecular biology,” with growing evidence that the authors' invertebrate passengers and all of their relatives also contain most of these subclasses and sequence Types.
Journal ArticleDOI
Intermediate filaments: primary determinants of cell architecture and plasticity
TL;DR: This work highlights the basic structural and functional properties of IFs and derives a concept of how mutations may affect cellular architecture and thereby tissue construction and physiology.
Journal ArticleDOI
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
TL;DR: Two of the three neurofilament genes of mammals have similar structures which are quite different from those of the other intermediate filaments, which suggests a common origin of the neuro Filament subunits, whose evolutionary relationship to other intermediate filament genes is uncertain.
References
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Book ChapterDOI
Sequencing end-labeled DNA with base-specific chemical cleavages.
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: The chapter presents techniques for producing discrete DNA fragments, end-labeling DNA, segregating end- labeled fragments, extracting DNA from gels, and the protocols for partially cleaving it at specific bases using the chemical reactions.
Journal ArticleDOI
A catalogue of splice junction sequences
TL;DR: The sequence CAAG/GTAGAGT was found to be a consensus of 139 exon-intron boundaries (or donor sequences) and (TC)nNCTAG/G was found of 130 intron-exon boundaries ( or acceptor sequences).
Journal ArticleDOI
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing
TL;DR: An approach to DNA sequencing using chain-terminating inhibitors (Sanger et al., 1977) combined with cloning of small fragments of DNA in a single-stranded DNA bacteriophage is described, determining the 2771-nucleotide sequence of the largest MboI restriction enzyme fragment from human mitochondrial DNA.
Journal ArticleDOI
3′ Non-coding region sequences in eukaryotic messenger RNA
TL;DR: A large selection of the 3′ non-coding regions of rabbit and human globin mRN As are 85% homologous, demonstrating that this region is significantly conserved in evolution.
Journal ArticleDOI
Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids
Arnold J. Berk,Phillip A. Sharp +1 more
TL;DR: A simple and sensitive method for detecting, sizing and mapping RNA transcripts from viral or cloned DNAs has been developed and used to examine the cytoplasmic transcripts produced during the early phase of adenovirus 2 (Ad2) infection of HeLa cells.
Related Papers (5)
The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins.
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