The tumor microenvironment.
Reads0
Chats0
TLDR
Early in tumor growth, a dynamic and reciprocal relationship develops between cancer cells and components of the tumor microenvironment that supports cancer cell survival, local invasion and metastatic dissemination.About:
This article is published in Current Biology.The article was published on 2020-08-17 and is currently open access. It has received 599 citations till now. The article focuses on the topics: Tumor microenvironment & Stromal cell.read more
Citations
More filters
Journal ArticleDOI
Conquering the Hypoxia Limitation for Photodynamic Therapy
TL;DR: In this article, a review of the recent progress in new nanomaterials designed to combat hypoxia and avoid the associated limitation of photodynamic therapy (PDT) is presented.
Journal ArticleDOI
Notch signaling pathway: architecture, disease, and therapeutics
TL;DR: In this article , a review of the history, architecture, regulatory mechanisms, contributions to physiological development, related diseases, and therapeutic applications of the NOTCH pathway is presented. But, the authors emphasize that the outcomes of NOTCH signaling are changeable and highly dependent on context.
Journal ArticleDOI
Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Jingjing Qi,Hongxiang Sun,Yao Zhang,Zhengting Wang,Zhenzhen Xun,Ziyi Li,X.D. Ding,Rujuan Bao,Liwen Hong,Wen-Qing Jia,Fei Fang,Hongzhi Liu,Lei Chen,Jie Zhong,Duo-Wu Zou,Lianxin Liu,Leng Han,Florent Ginhoux,Yingbin Liu,Youqiong Ye,Bingwei Su +20 more
TL;DR: In this paper , the tumor-specific FAP+ fibroblasts and SPP1+ macrophages were positively correlated in 14 independent CRC cohorts containing 2550 samples and validate their close localization by immuno-fluorescent staining and spatial transcriptomics.
Journal ArticleDOI
Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response.
TL;DR: In this article, the authors defined the functions of the spatial architecture of the tumor immune microenvironment (TIME) in tumor biology and the effects of the gradient of extracellular nonspecific chemicals (ENSCs) on the TIME.
Journal ArticleDOI
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
Jorge Luis Galeano Niño,Hanrui Wu,Kaitlyn D. LaCourse,Andrew G Kempchinsky,Alex A Baryiames,Brittany Barber,Neal D. Futran,Jeffrey J. Houlton,Cassandra L. Sather,Ewa Sicinska,A. Taylor,Samuel S. Minot,Christopher D Johnston,Susan Bullman +13 more
TL;DR: This article used GeoMx spatial profiling and single-cell RNA sequencing to identify cell-associated bacteria and the host cells with which they interact, as well as uncovering alterations in transcriptional pathways that are involved in inflammation, metastasis, cell dormancy and DNA repair.
References
More filters
Journal ArticleDOI
The Tumor Microenvironment Innately Modulates Cancer Progression
TL;DR: Cross-talk between cancer cells and the proximal immune cells ultimately results in an environment that fosters tumor growth and metastasis, and understanding the nature of this dialog will allow for improved therapeutics that simultaneously target multiple components of the TME, increasing the likelihood of favorable patient outcomes.
Journal ArticleDOI
Immunological hallmarks of stromal cells in the tumour microenvironment
TL;DR: Evidence thatStromal determinants interact with leukocytes and influence antitumour immunity is discussed, with emphasis on the immunological attributes of stromal cells that may foster their protumorigenic function.
Journal ArticleDOI
Metabolic Interactions in the Tumor Microenvironment
TL;DR: The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.
Journal ArticleDOI
Tumor-associated stromal cells as key contributors to the tumor microenvironment
Karen M. Bussard,Karen M. Bussard,Lysette A. Mutkus,Kristina Stumpf,Candelaria Gomez-Manzano,Frank C. Marini +5 more
TL;DR: The current literature pertaining to the origins of recruited host stroma, contributions toward tumor progression, tumor-associated stromal cells, and mechanisms of crosstalk between endogenous hostStroma and tumor cells are reviewed.
Journal ArticleDOI
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
TL;DR: The current understanding of the physical, cellular, and molecular mechanisms by which the pathological tumor ECM affects the efficiency of radio-, chemo-, and immunotherapy is highlighted.
Related Papers (5)
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more