Journal ArticleDOI
The use of diglyceride kinase for quantifying ceramide.
David K. Perry,Yusuf A. Hannun +1 more
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This article is published in Trends in Biochemical Sciences.The article was published on 1999-06-01. It has received 52 citations till now. The article focuses on the topics: Ceramide.read more
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Ceramide in apoptosis: an overview and current perspectives.
TL;DR: This review summarizes recent findings and discusses insights from studies of ceramide metabolism, topology, and effector actions, promising an accelerated phase in defining the molecular and biochemical details of the role of Ceramide in apoptosis.
Journal ArticleDOI
Ceramide in the eukaryotic stress response
Yusuf A. Hannun,Chiara Luberto +1 more
TL;DR: Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation by regulating enzymes involved in its metabolism.
Journal ArticleDOI
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Francesca Scarlatti,Chantal Bauvy,Annamaria Ventruti,Giusy Sala,Françoise Cluzeaud,Alain Vandewalle,Riccardo Ghidoni,Patrice Codogno +7 more
TL;DR: The control of macroautophagy by ceramide provides a novel function for this lipid mediator in a cell process with major biological outcomes.
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Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.
TL;DR: Results indicate that the ceramide-induced membrane permeability increases in isolated mitochondria are via ceramide channel formation and not a release mechanism, as the channels that allow cytochrome c to freely permeate are reversible, and are not specific to cytochromec.
References
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Journal ArticleDOI
Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range
Sidney Udenfriend,Stanley Stein,Peter Böhlen,Wallace Dairman,Willy Leimgruber,Manfred Weigele +5 more
TL;DR: Fluorescamine is a new reagent for the detection of primary amines in the picomole range that is almost instantaneous at room temperature in aqueous media and the products are highly fluorescent, whereas the reagent and its degradation products are nonfluorescent.
Journal ArticleDOI
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.
TL;DR: Data are consistent with the K-ras protein functioning in transmembrane signalling by activating phospholipase C and Protein kinase C (Ca2+/phospholipid-dependent enzyme) activation by DAG may play an important role in cellular transformation.
Book
Handbook of derivatives for chromatography
TL;DR: In this paper, Blau et al. present an approach for the esterification of Esterification (K. Blau and A. Darbre), which is based on the derivatization for fast atom/Ion bombardment Mass Spectrometry (R. Evershed).
Journal ArticleDOI
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
TL;DR: Results suggest that sphingomyelin turnover may be an important signaling mechanism transducing the actions of TNF alpha and gamma-IFN with specific function in cell differentiation.
Journal ArticleDOI
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
Ruggero De Maria,Luisa Lenti,Luisa Lenti,Florence Malisan,Florence Malisan,Federica D'Agostino,Federica D'Agostino,Barbara Tomassini,Barbara Tomassini,Ann Zeuner,Ann Zeuner,Maria Rita Rippo,Maria Rita Rippo,Roberto Testi,Roberto Testi +14 more
TL;DR: GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells and Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides preventedCD95-induced apoptosis.