Journal ArticleDOI
Ceramide in the eukaryotic stress response
Yusuf A. Hannun,Chiara Luberto +1 more
TLDR
Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation by regulating enzymes involved in its metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2000-02-01. It has received 729 citations till now. The article focuses on the topics: Lipid signaling & Ceramide.read more
Citations
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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
TL;DR: A unifying hypothesis is proposed whereby hyperglycemia and FFA-induced activation of the nuclear factor-kappaB, p38 MAPK, and NH2-terminal Jun kinases/stress-activated protein kinases stress pathways plays a key role in causing late complications in type 1 and type 1 diabetes, along with insulin resistance and impaired insulin secretion in type 2 diabetes.
Journal ArticleDOI
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar,Sovan Sarkar,Janet E. Davies,Marie Futter,Moisés García-Arencibia,Zeyn W. Green-Thompson,Maria Jimenez-Sanchez,Viktor I. Korolchuk,Maike Lichtenberg,Shouqing Luo,Dunecan Massey,Fiona M. Menzies,Kevin Moreau,Usha Narayanan,Maurizio Renna,Farah H. Siddiqi,Benjamin R. Underwood,Ashley R. Winslow,David C. Rubinsztein +18 more
TL;DR: This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.
Journal ArticleDOI
CHARMM-GUI Membrane Builder Toward Realistic Biological Membrane Simulations
Emilia L. Wu,Xi Cheng,Sunhwan Jo,Huan Rui,Kevin C. Song,Eder M. Dávila-Contreras,Yifei Qi,Jumin Lee,Viviana Monje-Galvan,Richard M. Venable,Jeffery B. Klauda,Wonpil Im +11 more
TL;DR: The new features and major improvements in Membrane Builder that allow users to robustly build realistic biological membrane systems are described, including addition of new lipid types, including phosphoinositides, cardiolipin (CL), sphingolipids, bacterial lipids, and ergosterol.
Journal ArticleDOI
Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
Xianlin Han,Richard W. Gross +1 more
TL;DR: This review will focus on the advances in ESI/MS, which have facilitated the development of shotgun lipidomics and the utility of intrasource separation as an enabling strategy for utilization of 2D mass spectrometry in Shotgun lipidomics of biological samples.
Journal ArticleDOI
Molecular machinery for non-vesicular trafficking of ceramide
Kentaro Hanada,Keigo Kumagai,Satoshi Yasuda,Yukiko Miura,Miyuki Kawano,Masayoshi Fukasawa,Masahiro Nishijima +6 more
TL;DR: It is concluded that CERT mediates the intracellular trafficking of ceramide in a non-vesicular manner.
References
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Journal ArticleDOI
Functions of Ceramide in Coordinating Cellular Responses to Stress
TL;DR: A spectrum of inducers of ceramide accumulation and the nature of Ceramide-mediated responses suggest that ceramide is a key component of intracellular stress response pathways.
Journal ArticleDOI
Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis
Pino Santana,Louis A. Peña,Adriana Haimovitz-Friedman,Seamus J. Martin,Douglas R. Green,Maureen McLoughlin,Carlos Cordon-Cardo,Edward H. Schuchman,Zvi Fuks,Richard Kolesnick +9 more
TL;DR: It is shown that lymphoblasts from Niemann-Pick patients, which have an inherited deficiency of acid sphingomyelinase activity, fail to respond to ionizing radiation with ceramide generation and apoptosis.
Journal ArticleDOI
Signal transduction of stress via ceramide
TL;DR: The sphingomyelin (SM) pathway is a ubiquitous, evolutionarily conserved signalling system analogous to conventional systems such as the cAMP and phosphoinositide pathways, and ceramide signalling mediates the therapeutic effects of chemotherapy and radiation in some cells.
Journal ArticleDOI
The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis
Santos A. Susin,Naoufal Zamzami,Maria Castedo,Eric Daugas,Hong Gang Wang,Stephan Geley,Florence Fassy,John C. Reed,Guido Kroemer +8 more
TL;DR: A protease activation pathway with the mitochondrial phase of apoptosis regulation is connected, providing a plausible explanation of why Bcl-2 fails to interfere with Fas-triggered apoptosis in most cell types, yet prevents ceramide- and prooxidant-induced apoptosis.cmk.
Journal ArticleDOI
Sphingolipids - The enigmatic lipid class: Biochemistry, physiology and pathophysiology
Alfred H. Merrill,Eva M. Schmelz,Dirck L. Dillehay,Sarah Spiegel,Shayman Ja,Joseph J. Schroeder,Ronald T. Riley,Kenneth A. Voss,Elaine Wang +8 more
TL;DR: Findings illustrate how an understanding of the function of sphingolipids can help solve questions in toxicology and this is undoubtedly only the beginning of this story.