The utility of urinary CD80 as a diagnostic marker in patients with renal diseases.
Shogo Minamikawa,Kandai Nozu,Shingo Maeta,Tomohiko Yamamura,Keita Nakanishi,Junya Fujimura,Tomoko Horinouchi,China Nagano,Nana Sakakibara,Hiroaki Nagase,Hideaki Shima,Kenta Noda,Takeshi Ninchoji,Hiroshi Kaito,Kazumoto Iijima +14 more
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TLDR
The results suggest that urinary CD80 is unreliable as a differential diagnostic marker between MCD in relapse and FSGS or inherited kidney diseases, and increased urinaryCD80 excretion was present in all patients with active kidney disease.Abstract:
CD80, which regulates T cell activation, may provide a differential diagnostic marker between minimal change disease (MCD) and other renal diseases, including focal segmental glomerular sclerosis (FSGS). However, recent reports show contrasting results. Therefore, we evaluated the utility of urinary CD80 as a diagnostic biomarker. We collected 65 urine samples from 55 patients with MCD (n = 31), FSGS (n = 4), inherited nephrotic syndrome (n = 4), Alport syndrome (n = 5) and other glomerular diseases (n = 11), and control samples (n = 30). We measured urinary CD80 levels by ELISA. Urinary CD80 (ng/gCr) (median, interquartile range) levels were significantly higher in patients with MCD in relapse (91.5, 31.1–356.0), FSGS (376.2, 62.7–1916.0), and inherited nephrotic syndrome (220.1, 62.9–865.3), than in patients with MCD in remission (29.5, 21.7–52.8) (p < 0.05). Elevation of urinary CD80 was observed, even in patients with inherited nephrotic syndrome unrelated to T cell activation. Additionally, urinary CD80 was positively correlated with urinary protein levels. Our results suggest that urinary CD80 is unreliable as a differential diagnostic marker between MCD in relapse and FSGS or inherited kidney diseases. Increased urinary CD80 excretion was present in all patients with active kidney disease.read more
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The Search for Biomarkers to Aid in Diagnosis, Differentiation, and Prognosis of Childhood Idiopathic Nephrotic Syndrome.
TL;DR: A review of urine- and serum-based biomarkers which could be used for the diagnosis, differentiation, and prognosis of nephrotic syndrome explores the most exciting biomarkers and their potential clinical applications.
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Urinary CD80 Discriminates Among Glomerular Disease Types and Reflects Disease Activity.
Anatilde Gonzalez Guerrico,John C. Lieske,George G. Klee,Sanjay Kumar,Victor Lopez-Baez,Adam M. Wright,Shane A. Bobart,Diane E. Shevell,M. Maldonado,Jonathan P. Troost,Marie C. Hogan +10 more
TL;DR: In proteinuric patients, CD80 concentration appears to be independent of proteinuria levels, suggesting that it is unrelated to nonspecific passage across the glomeruli.
Journal ArticleDOI
Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse
Gabriel Cara-Fuentes,Madhusudan Venkatareddy,Rakesh Verma,Alfons Segarra,Audrey C. A. Cleuren,Alfonso Martínez-Ramos,Richard J. Johnson,Puneet Garg +7 more
TL;DR: Glomerular endothelial cells and podocytes can express CD80 in patients with MCD during relapse and in the LPS mouse model of podocyte injury, in a similar pattern to that seen in MCD patients.
Journal ArticleDOI
An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome
TL;DR: A recent review as mentioned in this paper describes an updated view of SSNS pathogenesis from immunological and genetic aspects, including interactions with infections or allergies, production of circulating factors, and an autoantibody hypothesis.
Journal ArticleDOI
CD80 expression and infiltrating regulatory T cells in idiopathic nephrotic syndrome of childhood.
Fehime Kara Eroglu,Diclehan Orhan,Mihriban İnözü,Ali Duzova,Bora Gülhan,Fatih Ozaltin,Rezan Topaloglu +6 more
TL;DR: This study evaluated CD80 expression and infiltrating Tregs in children with MCD and FSGS and found that ineffective circulating Treg response is involved in the pathogenesis of nephrotic syndrome.
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