Three Different Neutrophil Subsets Exhibited in Mice with Different Susceptibilities to Infection by Methicillin-Resistant Staphylococcus aureus
Yasuhiro Tsuda,Hitoshi Takahashi,Makiko Kobayashi,Makiko Kobayashi,Toshiaki Hanafusa,David N. Herndon,Fujio Suzuki,Fujio Suzuki +7 more
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TLDR
It is shown that in addition to normal PMN (PMN-N), there are at least two distinct subsets of PMNs (PMn-I and PMN-II) distinguished as follows: cytokine and chemokine production and surface antigen expression.About:
This article is published in Immunity.The article was published on 2004-08-01 and is currently open access. It has received 369 citations till now. The article focuses on the topics: CCL3 & TLR2.read more
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Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
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Neutrophils and immunity: challenges and opportunities.
TL;DR: Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich the concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.
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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Zvi G. Fridlender,Jing Sun,Samuel Kim,Veena Kapoor,Guanjun Cheng,Leona E. Ling,G. Scott Worthen,Steven M. Albelda +7 more
TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.
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Neutrophils in the activation and regulation of innate and adaptive immunity
TL;DR: Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens, but more recent evidence has extended the functions of these cells.
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Macrophage plasticity and polarization in tissue repair and remodelling.
TL;DR: Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M1 or an M2‐like activation mode.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Mechanisms of phagocytosis in macrophages
Alan Aderem,David M. Underhill +1 more
TL;DR: Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
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M-1/M-2 macrophages and the Th1/Th2 paradigm.
TL;DR: The results indicate that M-1- or M-2-dominant macrophage responses can influence whether Th1/Th2 or other types of inflammatory responses occur.
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