Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors.
Hugo Aguilar-Díaz,Rosa Estela Quiroz-Castañeda,Karina Salazar-Morales,Raquel Cossío-Bayúgar,Estefan Miranda-Miranda +4 more
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TLDR
In this article, the actors of these responses are the object of a study in this review since they are new targets in anti-tick vaccine design, and they present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed.Abstract:
Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines.read more
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Advances in the Immunobiology of Parasitic Diseases
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Patrícia Gonzaga Paulino,Maristela Peckle,Leo Paulis Mendonça,Carlos Luiz Massard,Sandra Antunes,Joana Couto,Ana Domingos,Daniel da Silva Guedes Junior,Alejandro Cabezas-Cruz,Huarrisson Azevedo Santos +9 more
TL;DR: In this article , the expression of genes involved in immune signaling pathways of R. microplus adults' guts when challenged with a high or low parasitic load of T. equi was evaluated.
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Tick and Tick-Borne Diseases: New Problems Providing New Possible Solutions
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References
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Journal ArticleDOI
BmiGI: a database of cDNAs expressed in Boophilus microplus, the tropical/southern cattle tick.
Felix D. Guerrero,Robert J. Miller,M.-E. Rousseau,Sirisha Sunkara,John Quackenbush,Y. Lee,Vishvanath Nene +6 more
TL;DR: A number of novel sequences were identified which possessed significant sequence similarity to genes, which might be involved in resistance to acaricides.
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A secreted cystatin from the tick Haemaphysalis longicornis and its distinct expression patterns in relation to innate immunity
Jinlin Zhou,Mami Ueda,Rika Umemiya,Badgar Battsetseg,Damdinsuren Boldbaatar,Xuenan Xuan,Kozo Fujisaki +6 more
TL;DR: Results indicated that cystatin Hlcyst-2, cloned from tick H. longicornis, is involved in tick innate immunity.
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Molecular characterization and related aspects of the innate immune response in ticks
TL;DR: The molecular events that activate the cellular processes and the array of humoral factors that are mobilized against invading organisms, including antimicrobial peptides, proteases and protease inhibitors, lectins, coagulation factors and others are described.
Journal ArticleDOI
Production of reactive oxygen species by hemocytes from the cattle tick Boophilus microplus.
TL;DR: Investigation of phagocytic activity and the production of reactive oxygen species (ROS) by hemocytes from the cattle tick Boophilus microplus indicates that tick hemocytes are able to produce ROS during the phagocytetic process similarly to vertebrate phagocytes.
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Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.
Sukanya Narasimhan,Tim J. Schuijt,Nabil M. Abraham,Nabil M. Abraham,Nallakkandi Rajeevan,Jeroen Coumou,Morven Graham,Andrew Robson,Ming-Jie Wu,Sirlei Daffre,Joppe W. Hovius,Erol Fikrig,Erol Fikrig +12 more
TL;DR: It is shown that a tick secreted protein (PIXR) modulates the tick gut microbiota and facilitates B. burgdorferi colonization and impairs larval molting, indicative of its role in tick biology.