Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors.
Hugo Aguilar-Díaz,Rosa Estela Quiroz-Castañeda,Karina Salazar-Morales,Raquel Cossío-Bayúgar,Estefan Miranda-Miranda +4 more
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TLDR
In this article, the actors of these responses are the object of a study in this review since they are new targets in anti-tick vaccine design, and they present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed.Abstract:
Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines.read more
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Advances in the Immunobiology of Parasitic Diseases
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TL;DR: In this paper , a review article explains different zoonotic diseases transmitted by various species of ticks and suggests use of various bait formulations and cultural control methods for deterring ticks from blood feeding.
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Patrícia Gonzaga Paulino,Maristela Peckle,Leo Paulis Mendonça,Carlos Luiz Massard,Sandra Antunes,Joana Couto,Ana Domingos,Daniel da Silva Guedes Junior,Alejandro Cabezas-Cruz,Huarrisson Azevedo Santos +9 more
TL;DR: In this article , the expression of genes involved in immune signaling pathways of R. microplus adults' guts when challenged with a high or low parasitic load of T. equi was evaluated.
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Tick and Tick-Borne Diseases: New Problems Providing New Possible Solutions
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