Tissue-specific expression of mouse α-amylase genes: Nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland
TLDR
The nucleotide sequence of two different mouse alpha-amylase mRNAs, one found in the pancreas and the other in the salivary gland, is determined, explaining previously observed differences in net charge and antigenic properties.About:
This article is published in Cell.The article was published on 1980-08-01 and is currently open access. It has received 201 citations till now. The article focuses on the topics: Peptide sequence & Nucleic acid sequence.read more
Citations
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Transcription termination and 3' processing: the end is in site!
TL;DR: In this article, it was shown that 3' cleavage of pre-mRNA in eukaryotes is, in many ways, the phenotypic equivalent of transcription termi-nation.
Journal ArticleDOI
Rates of DNA sequence evolution differ between taxonomic groups
TL;DR: Examination of available measurements shows that rates of DNA change of different phylogenetic groups differ by a factor of 5, with the slowest rates observed for higher primates and some bird lineages, while faster rates are seen in rodents, sea urchins, and drosophila.
Journal ArticleDOI
The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs
Molly Fitzgerald,Thomas Shenk +1 more
TL;DR: Three effects of deletion mutations on polyadenylation of late SV40 mRNAs are observed, including a 16 bp deletion that includes the AAUAAA sequence that prevents poly(A) addition.
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The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
TL;DR: The cDNA for the receptor that mediates the endocytosis and transcellular transport of IgA and IgM across many glandular epithelia into external secretions is cloned and sequenced.
Journal ArticleDOI
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
James C. Scott,Mark Selby,Mickey S. Urdea,Margarita Quiroga,Graeme I. Bell,William J. Rutter +5 more
TL;DR: The nucleotide sequence of a submaxillary cDNA encoding the mouse NGF precursor (preproNGF) is reported, in contrast to previous suppositions, where the NGF moiety is situated near the carboxy-terminus of the polyprotein precursor.
References
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A new method for sequencing DNA
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: Reactions that cleave DNA preferentially at guanines, at adenines,At cytosines and thymines equally, and at cytosine alone are described.
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Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.
TL;DR: In this article, it was shown that in vitro completion of these nascent light chains resulted in the synthesis of some chains having the same mol wt as the authentic secreted light chain, because of completion of in vivo proteolytically processed chains and of other chains which, due to the completion of unprocessed chains, have the same moll wt, as the precursor of the light chain.
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3′ Non-coding region sequences in eukaryotic messenger RNA
TL;DR: A large selection of the 3′ non-coding regions of rabbit and human globin mRN As are 85% homologous, demonstrating that this region is significantly conserved in evolution.
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Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor.
Shigetada Nakanishi,Akira Inoue,Toru Kita,Masahiro Nakamura,Annie C. Y. Chang,Stanley N. Cohen,Shosaku Numa +6 more
TL;DR: The nucleotide sequence of a 1,091-base pair cloned cDNA insert encoding bovine corticotropin-β-lipotropin precursor mRNA indicates that the precursor protein consists of repetitive units and includes a third melanotropin sequence in its cryptic portion.
Journal ArticleDOI
Methylmercury as a reversible denaturing agent for agarose gel electrophoresis.
James M. Bailey,Norman Davidson +1 more
TL;DR: It appears that complete denaturation of any base-paired secondary structural feature of a nucleic aicd can be achieved at practical concentrations of CH3HgOH.
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