Journal ArticleDOI
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
Vassilios Papadopoulos,Mario Baraldi,Tomás R. Guilarte,Thomas B. Knudsen,Jean Jacques Lacapère,Peter Lindemann,Michael D. Norenberg,David J. Nutt,Abraham Weizman,Ming Rong Zhang,Moshe Gavish +10 more
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TLDR
Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein, to represent more accurately its sub cellular role (or roles) and putative tissue-specific function (or functions).About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2006-08-01. It has received 1264 citations till now. The article focuses on the topics: Translocator protein & Cholesterol import.read more
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Membrane lipids: where they are and how they behave.
TL;DR: How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functions of their individual membranes?
Journal ArticleDOI
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
TL;DR: Recently, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs as mentioned in this paper.
Journal ArticleDOI
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications
TL;DR: This review of molecular imaging of intact living subjects focuses specifically on small molecules, peptides, aptamers, engineered proteins, and nanoparticles and cites examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics.
Journal ArticleDOI
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rainer Rupprecht,Vassilios Papadopoulos,Gerhard Rammes,Thomas C. Baghai,Jinjiang Fan,Nagaraju Akula,Ghislaine Groyer,David H. Adams,Michael Schumacher +8 more
TL;DR: The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system, which is a prerequisite for steroid synthesis.
Book ChapterDOI
Neurosteroids: Endogenous role in the human brain and therapeutic potentials
TL;DR: Synthetic neurosteroids that exhibit better bioavailability and efficacy and drugs that enhance neurosteroid synthesis have therapeutic potential in anxiety, epilepsy, and other brain disorders.
References
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Journal ArticleDOI
TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Journal ArticleDOI
In-vivo measurement of activated microglia in dementia
Annachiara Cagnin,David J. Brooks,A. M. Kennedy,Roger N. Gunn,Ralph Myers,Federico Turkheimer,Terry Jones,Richard B. Banati,Richard B. Banati +8 more
TL;DR: In-vivo detection of increased [11C](R)-PK11195 binding in Alzheimer-type dementia, including mild and early forms, suggests that microglial activation is an early event in the pathogenesis of the disease.
Journal ArticleDOI
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
TL;DR: The mitochondrial benzodiazepine receptor has been solubilized with retention of reversible ligand binding, and the associated subunits were characterized, finding that VDAC and ADC, outer and inner mitochondrial membrane channel proteins, respectively, together with the 18-kDa subunit, may comprise mBzR at functionally important transport sites at the junction of two mitochondrial membranes.
Journal Article
Enigma of the peripheral benzodiazepine receptor.
Moshe Gavish,Idit Bachman,Rami Shoukrun,Yeshayahu Katz,Leo Veenman,Gary Weisinger,Abraham Weizman +6 more
TL;DR: Benzodiazepines (BZs)2 are used clinically as muscle relaxants, anticonvulsants, anxiolytics, and sedative-hypnotics.
Journal ArticleDOI
High densities of benzodiazepine receptors in human cortical areas
TL;DR: It is reported here that benzodiazepine receptors are also present in the human brain, that the cerebral and cerebellar cortical regions contain the highest densities of binding sites and that the receptors in human brain are very similar to those in rat brain.
Related Papers (5)
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair.
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An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
David R. Owen,Astrid Yeo,Roger N. Gunn,Roger N. Gunn,Roger N. Gunn,Kijoung Song,Graham Wadsworth,Andrew J.M. Lewis,Christopher J. Rhodes,David J Pulford,Idriss Bennacef,Christine A. Parker,Christine A. Parker,Pamela Stjean,Lon R. Cardon,Vincent Mooser,Paul M. Matthews,Paul M. Matthews,Eugenii A. Rabiner,Eugenii A. Rabiner,Justin P. Rubio +20 more