Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies
Hanxin Liu,Huifang Zhao,Yu Sun +2 more
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TLDR
The tumor microenvironment (TME) is a major contributor to cancer malignancy including development of therapeutic resistance, a process mediated in part through intercellular crosstalk.About:
This article is published in Seminars in Cancer Biology.The article was published on 2021-11-16 and is currently open access. It has received 19 citations till now. The article focuses on the topics: Tumor microenvironment & Senescence.read more
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Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signaling
Baoai Han,He Zhang,Ruinan Tian,Hui Liu,Zhaosong Wang,Zhiyong Wang,Jianfei Tian,Yanfen Cui,Sixin Ren,Xiaoyan Zuo,Ran Tian,Ruifang Niu,Fei Zhang +12 more
TL;DR: It is demonstrated that exosomes produced by HM breast cancer cells can promote angiogenesis and metastasis and targeting the exosomal EPHA2-AMPK signaling may serve as a potential strategy for breast cancer therapy.
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Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses
TL;DR:
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Identification of several senescence‐associated genes signature in head and neck squamous cell carcinoma
TL;DR: The prognosis of senescence‐associated genes (SAGs) signature in head and neck squamous cell carcinoma (HNSCC) remains to be further evaluated.
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Comprehensive analysis of molecular features, prognostic values, and immune landscape association of m6A-regulated immune-related lncRNAs in smoking-associated lung squamous cell carcinoma
TL;DR: In this study, the expression and mutation features of the 24 m6A-related regulators in the smoking-associated LUSC cohort are described and a lncRNA-associated risk model is established and the clinical features, prognosis, immune landscape, and drug sensitivity are exhaustively clarified.
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Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization
Hao Liu,Dong Zhao,Huayi Li,Wenxin Zhang,Qingyu Lin,Xingwen Wang,Shanliang Zheng,Lei Zhang,Li Li,Shaoshan Hu,Ying Hu +10 more
TL;DR: In this paper , the authors show that nuclear erythroid factor 2-like factor 2 (Nrf2), a master antioxidative transcription factor, accumulates upon doxorubicin-induced senescence.
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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.