Journal ArticleDOI
Tunable pH- and Temperature-Sensitive Copolymer Libraries by Reversible Addition−Fragmentation Chain Transfer Copolymerizations of Methacrylates
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In this article reversible addition-fragmentation chain transfer (RAFT) polymerizations have been performed on a Chemspeed Accelerator SLT100 automated synthesizer to polymerize N,N-(dimethylamino)ethyl methacrylate (DMAEMA) and poly(ethylene glycol) methyl ether methacyl (PEGMA) at 70 °C. All polydispersity indices of the obtained copolymers are comprised between 1.11 and 1.30.Abstract:
Reversible addition−fragmentation chain transfer (RAFT) polymerizations have been performed on a Chemspeed Accelerator SLT100 automated synthesizer to polymerize N,N-(dimethylamino)ethyl methacrylate (DMAEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) at 70 °C. Azobis(isobutyronitrile) (AIBN) was used as source of radicals and 2-cyano-2-butyl dithiobenzoate (CBDB) as RAFT agent. A complete screening in composition of P(DMAEMA-stat-PEGMA) copolymers was elaborated from 0% of PEGMA to 100% of PEGMA. All polydispersity indices of the obtained copolymers are comprised between 1.11 and 1.30. The reactivity ratios have been determined by the extended Kelen−Tudos method (rDMAEMA = 0.93 and rPEGMA = 0.66). The behavior of the pH- and temperature-sensitive copolymers was studied in aqueous solution by measuring the lower critical solution temperature (LCST) by UV/vis spectroscopy. The measurements were performed at three different pH values (4, 7, and 10). At pH 7 and pH 10 it has been observed th...read more
Citations
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Living Radical Polymerization by the RAFT Process - A Second Update
TL;DR: The authors provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(S)SR) by a mechanism of reversible addition-fragmentation chain transfer (RAFT) that was published in June 2005.
Journal ArticleDOI
Thermoresponsive hydrogels in biomedical applications.
Leda Klouda,Antonios G. Mikos +1 more
TL;DR: The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change and focuses mainly on hydrogels based on natural polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.
Journal ArticleDOI
New directions in thermoresponsive polymers.
TL;DR: By highlighting recent examples of newly developed thermoresponsive polymer systems, it is hoped to promote the development of new generations of smart materials.
Journal ArticleDOI
Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s
TL;DR: In this article, a review of the thermodynamic properties of two important polymer classes in aqueous solution, namely poly(2-oxazoline)s and poly(ethylene oxide)s, is presented.
Journal ArticleDOI
Reversible-deactivation radical polymerization (Controlled/living radical polymerization): From discovery to materials design and applications
Nathaniel Corrigan,Kenward Jung,Graeme Moad,Craig J. Hawker,Krzysztof Matyjaszewski,Cyrille Boyer +5 more
TL;DR: Reversible-deactivation radical polymerization (RDRP) as mentioned in this paper is one of the most widely used techniques in polymer synthesis. But it has not yet been widely used in the field of biomedical applications.
References
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Journal ArticleDOI
Living free-radical polymerization by reversible addition - Fragmentation chain transfer: The RAFT process
John Chiefari,Y. K. Chong,Frances Ercole,Julia Krstina,Justine Leigh Jeffery,Tam P. T. Le,Roshan T. A. Mayadunne,Gordon Francis Meijs,Catherine Louise Moad,Graeme Moad,Ezio Rizzardo,San H. Thang +11 more
TL;DR: The authors proposed a reversible additive-fragmentation chain transfer (RAFT) method for living free-radical polymerization, which can be used with a wide range of monomers and reaction conditions and in each case it provides controlled molecular weight polymers with very narrow polydispersities.
Journal ArticleDOI
Living radical polymerization by the RAFT process
TL;DR: A review of living radical polymerization achieved with thiocarbonylthio compounds by a mechanism of reversible addition-fragmentation chain transfer (RAFT) is presented in this article.
Journal ArticleDOI
Linear method for determining monomer reactivity ratios in copolymerization
Morton A. Fineman,Sidney D. Ross +1 more
Journal ArticleDOI
Contact angle measurement and contact angle interpretation
Daniel Y. Kwok,A. W. Neumann +1 more
TL;DR: In this paper, it is shown that the controversy with respect to measurement and interpretation of contact angles is due to the fact that some (or all) of the assumptions made in all energetic approaches are violated when contact angles are measured and processed.
Journal ArticleDOI
'Smart' polymers and what they could do in biotechnology and medicine.
Igor Yu. Galaev,Bo Mattiasson +1 more
TL;DR: Stimulus-responsive or 'smart' polymers undergo strong conformational changes when only small changes in the environment occur, resulting in phase separation from aqueous solution or order-of-magnitude changes in hydrogel size.